The elderly may represent a specific cluster of high-risk patients for developing COVID-19
with rapidly progressive clinical deterioration. Indeed, in older individuals …

Aging is a complex biological process characterized by hallmark features accumulating over
the life course, shaping the individual's aging trajectory and subsequent disease risks. There …

The existence of a sex gap in human health and longevity has been widely documented.
Autosomal DNA methylation differences between males and females have been reported …

Background Loss of epigenetic control is a hallmark of aging. Among the most prominent
roles of epigenetic mechanisms is the inactivation of one of two copies of the X chromosome …

Although DNA methylation variation of autosomal CpGs provides robust age predictive
biomarkers, no male-specific age predictor exists based on Y-CpGs yet. Since sex …

Background Uterine corpus endometrial carcinoma (UCEC) tightly correlates with
dysregulated iron homeostasis. MGST1 (microsomal glutathione S‐transferase 1) involves …

Sex differences in human survival have been extensively investigated in many studies that
have in part uncovered the biological determinants that promote a longer life in females with …

Background DNA analysis for forensic investigations has a long tradition with important
developments and optimizations since its first application. Traditionally, short tandem …

Mosaicism in blood varies with age, and cross-sectional studies indicate that for women,
skewness of X-chromosomal mosaicism increases with age. This pattern could, however …

The early-life environment can profoundly shape the trajectory of an animal's life, even years
or decades later. One mechanism proposed to contribute to these early-life effects is DNA …