Transcription factors (TFs) recognize specific DNA sequences to control chromatin and
transcription, forming a complex system that guides expression of the genome. Despite keen …

Summary Foxp3+ T‐regulatory cells (Tregs) are primarily generated in the thymus (tTreg),
but also may be generated extrathymically at peripheral sites (pTreg), or induced in cell …

Background Despite recent progress, multiple myeloma remains incurable. Mezigdomide is
a novel cereblon E3 ubiquitin ligase modulator with potent antiproliferative and tumoricidal …

Background Iberdomide, a cereblon modulator promoting degradation of the transcription
factors Ikaros and Aiolos, which affect leukocyte development and autoimmunity, is being …

Malignant tumors can evade destruction by the immune system by attracting immune-
suppressive regulatory T cells (Treg) cells. The IKZF2 (Helios) transcription factor plays a …

Immunomodulatory drugs bind to cereblon (CRBN) to confer differentiated substrate
specificity on the CRL4CRBN E3 ubiquitin ligase. Here we report the identification of a new …

It is now clear that previously polarized T cells possess the ability to change their phenotype
and repolarize towards different fates. This intrinsic flexibility is commonly referred to as …

The drugs lenalidomide and pomalidomide bind to the protein cereblon, directing the CRL4–
CRBN E3 ligase toward the transcription factors Ikaros and Aiolos to cause their …

Proteolysis‐targeting chimeras are a new drug modality that exploits the endogenous
ubiquitin proteasome system to degrade a protein of interest for therapeutic benefit. As the …

Background Common variable immunodeficiency (CVID) is characterized by late-onset
hypogammaglobulinemia in the absence of predisposing factors. The genetic cause is …