Orphan G protein-coupled receptors: the ongoing search for a home
A Jobe, R Vijayan - Frontiers in Pharmacology, 2024 - frontiersin.org
G protein-coupled receptors (GPCRs) make up the largest receptor superfamily, accounting
for 4% of protein-coding genes. Despite the prevalence of such transmembrane receptors, a …
for 4% of protein-coding genes. Despite the prevalence of such transmembrane receptors, a …
The oxytocin receptor represents a key hub in the GPCR heteroreceptor network: Potential relevance for brain and behavior
DO Borroto-Escuela, C Cuesta-Marti… - Frontiers in Molecular …, 2022 - frontiersin.org
In the last 10 years, it has become increasingly clear that large numbers of axon collaterals
extend from the oxytocin (OXT) hypothalamic axons, especially the parvocellular …
extend from the oxytocin (OXT) hypothalamic axons, especially the parvocellular …
Decrypting orphan GPCR drug discovery via multitask learning
WC Huang, WT Lin, MS Hung, JC Lee… - Journal of …, 2024 - Springer
The drug discovery of G protein-coupled receptors (GPCRs) superfamily using
computational models is often limited by the availability of protein three-dimensional (3D) …
computational models is often limited by the availability of protein three-dimensional (3D) …