Studying the complex molecular mechanisms involved in traumatic brain injury (TBI) is
crucial for developing new therapies for TBI. Current treatments for TBI are primarily focused …

Glutamate is present in the brain at an average concentration—typically 10–12 mM—far in
excess of those of other amino acids. In glutamate-containing vesicles in the brain, the …

Glutamate is the major excitatory neurotransmitter in the nervous system, where it induces
multiple beneficial and essential effects. Yet, excess glutamate, evident in a kaleidoscope of …

Traumatic brain injury (TBI) is associated with significant cognitive and psychiatric
conditions. Neuropsychiatric symptoms can persist for years following brain injury, causing …

Glutamate excitotoxicity is a primary contributor of ischemic neuronal death and other
cellular components of the neurovascular unit. Several strategies have been developed …

Much work has been carried out in recent years showing that elevated glutamate levels in
the extracellular environment of the central nervous system play a pivotal role in …

The advent of epigenetics brought in a tectonic shift in the understanding of molecular basis
of complex diseases like ischemic stroke (IS). Substantial scientific inquiry into the …

Depression is a significant cause of disability and affects millions worldwide; however,
antidepressant therapies often fail or are inadequate. Current medications for treating major …

Background Glutamate oxaloacetate transaminase 1 (GOT1) regulates cellular metabolism
through coordinating the utilization of carbohydrates and amino acids to meet nutrient …

Objective Blood/brain‐glutamate grabbing is an emerging concept in the treatment of acute
ischemic stroke, where essentially the deleterious effects of glutamate after ischemia are …