Summary Sporadic Creutzfeldt-Jakob disease is a fatal neurodegenerative disease caused
by misfolded prion proteins (PrP Sc). Effective therapeutics are currently not available and …

Alzheimer's disease (AD) is a progressive neurodegenerative disease with a complex and
heterogeneous pathophysiology. The number of people living with AD is predicted to …

Synapses are the site for brain communication where information is transmitted between
neurons and stored for memory formation. Synaptic degeneration is a global and early …

Background An unmet clinical need in Parkinson's disease (PD) is to identify biomarkers for
diagnosis, preferably in peripherally accessible tissues such as skin. Immunohistochemical …

Neurodegenerative diseases are a heterogeneous group of maladies, characterized by
progressive loss of neurons. These diseases involve an intricate pattern of cross-talk …

Background YKL-40 (also known as Chitinase 3-like 1) is a glycoprotein produced by
inflammatory, cancer and stem cells. Its physiological role is not completely understood but …

Parkinson's disease (PD) comprises a spectrum of disorders with differing subtypes, the vast
majority of which share Lewy bodies (LB) as a characteristic pathological hallmark. The …

Abstract Sporadic Creutzfeldt–Jakob disease (CJD), the most common human prion
disease, is generally regarded as a spontaneous neurodegenerative illness, arising either …

Neurodegenerative diseases are characterised by the irreversible degeneration of neurons
in the central or peripheral nervous systems. These include amyotrophic lateral sclerosis …

Genetic prion diseases are a rare and diverse group of fatal neurodegenerative disorders
caused by pathogenic sequence variations in the prion protein gene, PRNP. Data on CSF …