Biological puzzles solved by using Streptococcus pneumoniae: a historical review of the pneumococcal studies that have impacted medicine and shaped molecular …
NL Hiller, CJ Orihuela - Journal of Bacteriology, 2024 - Am Soc Microbiol
The major human pathogen Streptococcus pneumoniae has been the subject of intensive
clinical and basic scientific study for over 140 years. In multiple instances, these efforts have …
clinical and basic scientific study for over 140 years. In multiple instances, these efforts have …
PspA-mediated aggregation protects Streptococcus pneumoniae against desiccation on fomites
Streptococcus pneumoniae (Spn) resides in the nasopharynx, where it can disseminate to
cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA) …
cause disease. One key Spn virulence factor is pneumococcal surface protein A (PspA) …
Anatomical site-specific carbohydrate availability impacts Streptococcus pneumoniae virulence and fitness during colonization and disease
Streptococcus pneumoniae colonizes the nasopharynx asymptomatically but can also cause
severe life-threatening disease. Importantly, stark differences in carbohydrate availability …
severe life-threatening disease. Importantly, stark differences in carbohydrate availability …
The choline-binding proteins PspA, PspC, and LytA of Streptococcus pneumoniae and their interaction with human endothelial and red blood cells
C Vilhena, S Du, M Battista, M Westermann… - Infection and …, 2023 - Am Soc Microbiol
Streptococcus pneumoniae is a Gram-positive opportunistic pathogen that can colonize the
upper respiratory tract. It is a leading cause of a wide range of infectious diseases, including …
upper respiratory tract. It is a leading cause of a wide range of infectious diseases, including …
Neuraminidase-mediated enhancement of Streptococcus pneumoniae colonization is associated with altered mucus characteristics and distribution
MT Montgomery, M Ortigoza, C Loomis, JN Weiser - mBio, 2024 - journals.asm.org
Upon entry into the upper respiratory tract (URT), Streptococcus pneumoniae (Spn)
upregulates neuraminidases (NA) that cleave sialic acid (SA) from host glycans. Because …
upregulates neuraminidases (NA) that cleave sialic acid (SA) from host glycans. Because …
Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors
V Minhas, A Domenech, D Synefiaridou, D Straume… - bioRxiv, 2022 - biorxiv.org
Competence development in the human pathogen Streptococcus pneumoniae controls
several features such as genetic transformation, biofilm formation and virulence. Competent …
several features such as genetic transformation, biofilm formation and virulence. Competent …