Metabolomics is a discipline aiming to characterize the presence of metabolites in biological
matrices under specific conditions. In recent years, metabolomics has increasingly been …

Stem cell-derived organoids are a promising tool to model native human tissues as they
resemble human organs functionally and structurally compared to traditional monolayer cell …

Growth factors secreted by stromal fibroblasts regulate the intestinal epithelium. Stroma-
derived epidermal growth factor (EGF) family ligands are implicated in epithelial …

A mechanism exploration is an important part of toxicological studies. However, traditional
cell and animal models can no longer meet the current needs for in-depth studies of …

Polybrominated diphenyl ethers (PBDEs) are a widely used class of brominated flame
retardants. Exposure to PBDEs could induce testicular damage in mammals, but the effects …

Doxorubicin is widely used in the treatment of different cancers, and its side effects can be
severe in many tissues, including the intestines. Symptoms such as diarrhoea and …

Ribosome quality control (RQC) resolves collided ribosomes, thus preventing their cytotoxic
effects. The chemotherapeutic agent 5-Fluorouracil (5FU) is best known for its …

We have built a quantitative systems toxicology modeling framework focused on the early
prediction of oncotherapeutic‐induced clinical intestinal adverse effects. The model …

Cross-species comparison of drug responses at the organoid level could help to determine
the human relevance of findings from animal studies. To this end, we first need to evaluate …

Background Recent evidences highlight role of mitochondria in the development of 5-
fluorouracil (5-FU)-induced intestinal toxicity. Mitochondria-targeted antioxidants are well …