Pharmaco-proteogenomic profiling of pediatric diffuse midline glioma to inform future treatment strategies
Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …
Can hemp help? Low-THC cannabis and non-THC cannabinoids for the treatment of cancer
Cannabis has been used to relieve the symptoms of disease for thousands of years.
However, social and political biases have limited effective interrogation of the potential …
However, social and political biases have limited effective interrogation of the potential …
Proteomic profiling of mouse epididymosomes reveals their contributions to post-testicular sperm maturation
The functional maturation of spermatozoa that is necessary to achieve fertilization occurs as
these cells transit through the epididymis, a highly specialized region of the male …
these cells transit through the epididymis, a highly specialized region of the male …
Blockade of ROS production inhibits oncogenic signaling in acute myeloid leukemia and amplifies response to precision therapies
Mutations in the type III receptor tyrosine kinase FLT3 are frequent in patients with acute
myeloid leukemia (AML) and are associated with a poor prognosis. AML is characterized by …
myeloid leukemia (AML) and are associated with a poor prognosis. AML is characterized by …
Mutant JAK3 phosphoproteomic profiling predicts synergism between JAK3 inhibitors and MEK/BCL2 inhibitors for the treatment of T-cell acute lymphoblastic …
S Degryse, CE De Bock, S Demeyer, I Govaerts… - Leukemia, 2018 - nature.com
Mutations in the interleukin-7 receptor (IL7R) or the Janus kinase 3 (JAK3) kinase occur
frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are able to drive cellular …
frequently in T-cell acute lymphoblastic leukemia (T-ALL) and both are able to drive cellular …
Acrylamide modulates the mouse epididymal proteome to drive alterations in the sperm small non-coding RNA profile and dysregulate embryo development
Paternal exposure to environmental stressors elicits distinct changes to the sperm sncRNA
profile, modifications that have significant post-fertilization consequences. Despite this …
profile, modifications that have significant post-fertilization consequences. Despite this …
Analysis of the small non-protein-coding RNA profile of mouse spermatozoa reveals specific enrichment of piRNAs within mature spermatozoa
K Hutcheon, EA McLaughlin, SJ Stanger… - RNA biology, 2017 - Taylor & Francis
Post-testicular sperm maturation and storage within the epididymis is a key determinant of
gamete quality and fertilization competence. Here we demonstrate that mouse spermatozoa …
gamete quality and fertilization competence. Here we demonstrate that mouse spermatozoa …
Extracellular vesicles with altered tetraspanin CD9 and CD151 levels confer increased prostate cell motility and invasion
To facilitate intercellular communication, cells release nano-sized, extracellular vesicles
(EVs) to transfer biological cargo to both local and distant sites. EVs are enriched in …
(EVs) to transfer biological cargo to both local and distant sites. EVs are enriched in …
Signal transduction in diffuse intrinsic pontine glioma
Diffuse intrinsic pontine glioma (DIPG) is an untreatable, heterogeneous high‐grade glioma
(HGG) of the brainstem. This highly aggressive cancer affects mostly young children and is …
(HGG) of the brainstem. This highly aggressive cancer affects mostly young children and is …
Targeting NF-κB signaling for multiple myeloma
Multiple myeloma (MM) is the second most common hematologic malignancy in the world.
Even though survival rates have significantly risen over the past years, MM remains …
Even though survival rates have significantly risen over the past years, MM remains …