A review of micronutrients and the immune system–working in harmony to reduce the risk of infection

AF Gombart, A Pierre, S Maggini - Nutrients, 2020 - mdpi.com
Immune support by micronutrients is historically based on vitamin C deficiency and
supplementation in scurvy in early times. It has since been established that the complex …

Roles of zinc signaling in the immune system

S Hojyo, T Fukada - Journal of immunology research, 2016 - Wiley Online Library
Zinc (Zn) is an essential micronutrient for basic cell activities such as cell growth,
differentiation, and survival. Zn deficiency depresses both innate and adaptive immune …

Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response

JP Liuzzi, LA Lichten, S Rivera… - Proceedings of the …, 2005 - National Acad Sciences
Infection and inflammation produce systemic responses that include hypozincemia and
hypoferremia. The latter involves regulation of the iron transporter ferroportin 1 by hepcidin …

Reprogramming of the immune system during zinc deficiency

PJ Fraker, LE King - Annu. Rev. Nutr., 2004 - annualreviews.org
▪ Abstract Thymic atrophy, lymphopenia, and compromised cell-and antibody-mediated
responses that cause increased rates of infections of longer duration are the immunological …

Intracellular zinc homeostasis and zinc signaling

M Murakami, T Hirano - Cancer science, 2008 - Wiley Online Library
Zinc (Zn) is an essential heavy metal that is incorporated into a number of human Zn
metalloproteins. Zn plays important roles in nucleic acid metabolism, cell replication, and …

Functional significance of zinc-related signaling pathways in immune cells

H Haase, L Rink - Annual review of nutrition, 2009 - annualreviews.org
Recent years have brought a paradigm shift for the role of the essential trace element zinc in
immunity. Although its function as a structural component of many enzymes has been known …

Micronutrients in autoimmune diseases: possible therapeutic benefits of zinc and vitamin D

I Wessels, L Rink - The Journal of nutritional biochemistry, 2020 - Elsevier
A functional immune system is essential for healthy life. This is achieved by the coordinate
activation and interaction of different immune cells. One should be aware that activation of …

[HTML][HTML] Trace elements and host defense: recent advances and continuing challenges

ML Failla - The Journal of nutrition, 2003 - Elsevier
Although it is widely recognized that essential trace elements are required for the
differentiation, activation and performance of numerous functions of immune cells, the …

Roles of zinc and zinc signaling in immunity: zinc as an intracellular signaling molecule

T Hirano, M Murakami, T Fukada, K Nishida… - Advances in …, 2008 - Elsevier
Zinc (Zn) is an essential nutrient required for cell growth, differentiation, and survival, and its
deficiency causes growth retardation, immunodeficiency, and other health problems …

Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression

M Li, Y Zhang, Z Liu, U Bharadwaj… - Proceedings of the …, 2007 - National Acad Sciences
Zinc is an essential trace element and catalytic/structural component used by many
metalloenzymes and transcription factors. Recent studies indicate a possible correlation of …