Breast cancer is one of the most prevalent malignancies in women worldwide. Early-stage
breast cancer is considered a curable disease; however, once distant metastasis occurs, the …

Breast cancer brain metastases are an increasing clinical problem. Studies have shown that
brain metastases from breast cancer have a distinct genomic landscape to that of the …

The molecular events and transcriptional plasticity driving brain metastasis in clinically
relevant breast tumor subtypes has not been determined. Here we comprehensively dissect …

Background Breast cancer subtypes are associated with distinct metastatic patterns.
Whether germline BRCA1/BRCA2 mutation status is independently associated with central …

Purpose: Prostate cancers with mutations in genes involved in homologous recombination
(HR), most commonly BRCA2, respond favorably to PARP inhibition and platinum-based …

Breast cancer with metastasis especially brain metastasis represents a significant cause of
morbidity and mortality in patients. In this study, we aimed to investigate the hub genes and …

Purpose: Limited effective treatments are currently available for central nervous system
(CNS) metastasis (CM). This is largely driven by the inability of current therapeutics to …

Simple Summary Breast cancer, the most common malignant tumor among women
worldwide, remains an incurable disease once it has spread to the brain. Past research has …

Tumor growth is the result of the interplay of complex biological processes in huge numbers
of individual cells living in changing environments. Effective simple mathematical laws have …

Improved survival rates for prostate cancer through more effective therapies have also led to
an increase in the diagnosis of metastases to infrequent locations such as the brain. Here …