Because nuclear factor-κB (NF-κB) is a ubiquitously expressed proinflammatory transcription
factor that regulates the expression of over 500 genes involved in cellular transformation …

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the
regulation of a large number of genes that are involved in important physiological …

Curcumin (diferuloylmethane) is a polyphenol derived from the Curcuma longa plant,
commonly known as turmeric. Curcumin has been used extensively in Ayurvedic medicine …

Purpose To evaluate the impact of the addition of bortezomib to rituximab,
cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) on outcomes in …

Oncogenic proteins cooperate to promote tumor development and progression by sustaining
cell proliferation, survival and invasiveness. Constitutive epidermal growth factor receptor …

TNFα is a key mediator of immune, chemotherapy and radiotherapy-induced cytotoxicity, but
several cancers, including head and neck squamous cell carcinomas (HNSCC), display …

This phase 2 study evaluated whether substituting bortezomib for vincristine in frontline
rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) …

Nrf2 and NF-κB transcription factors act in wound healing via their anti-inflammatory and anti-
oxidant effects or through the immune response. Studying this process is a matter of some …

Head and neck squamous cell carcinoma (HNSCC) and many other epithelial malignancies
exhibit increased proliferation, invasion, and inflammation, concomitant with aberrant …

Retreatment of recurrent or second primary head and neck cancers occurring in a previously
irradiated field is complex. Few guidelines exist to support practice. We performed an …