Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …

Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

Adrenal aldosterone-producing adenomas (APAs) constitutively produce the salt-retaining
hormone aldosterone and are a common cause of severe hypertension. Recurrent …

Background Migraine is a disabling and chronic neurovascular headache disorder.
Trigeminal vascular activation and release of calcitonin gene-related peptide (CGRP) play a …

Voltage-gated calcium (Ca 2+) channels initiate release of neurotransmitters at synapses,
and regulation of presynaptic Ca 2+ channels has a powerful influence on synaptic strength …

Migraine is a common, disabling, multifactorial, episodic neurovascular disorder of unknown
etiology. Familial hemiplegic migraine type 1 (FHM-1) is a Mendelian subtype of migraine …

Migraine—an episodic headache—affects more than 10% of the general population.
Despite recent progress, drug therapy for preventing and treating migraine remains …

Background Familial hemiplegic migraine, an autosomal dominant disorder characterized
by attacks of transient hemiparesis followed by a migraine headache, is divided into pure …

Neurones in the trigeminocervical complex are the major relay neurones for nociceptive
afferent input from the meninges and cervical structures; therefore, they are the neural …

Migraine is a common disabling brain disorder. A subtype of migraine with aura (familial
hemiplegic migraine type 1: FHM1) is caused by mutations in Ca V 2.1 (P/Q-type) Ca 2+ …