Background: Tissues, such as skeletal muscle, have been targeted for the delivery of
plasmid DNA (pDNA) encoding vaccines and therapeutics. The application of electric pulses …

Gene electrotransfer (GET) has recently emerged as an effective nonviral approach for
plasmid DNA (pDNA) delivery in gene therapy for several pathologies, including cancer …

Gene therapy approaches may target skeletal muscle due to its high protein-expressing
nature and vascularization. Intramuscular plasmid DNA (pDNA) delivery via pulsed electric …

Our previous study discovered that sucrose and other non-reducing sugars (eg, trehalose
and raffinose) could be used to improve the electrotransfer (ET) of molecular cargo …

DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on
plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for …

Background: Models of muscle cell culture allow simple manipulation to optimize gene
transfer experiments, offering a significant opportunity to model muscle effects by allowing …