There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has
many roles in female and male reproduction, as a neuropeptide in the central nervous …

Cardiovascular disease is a leading cause of death worldwide and there is a pressing need
for new therapeutic strategies to treat such conditions. The risk of developing cardiovascular …

Background Serelaxin is a recombinant form of human relaxin-2, a vasodilator hormone that
contributes to cardiovascular and renal adaptations during pregnancy. Previous studies …

Objectives: The aim of this study was to assess the effects of serelaxin on short-term
changes in markers of organ damage and congestion and relate them to 180-day mortality …

Certain lower vertebrates like zebrafish activate proliferation of spared cardiomyocytes after
cardiac injury to regenerate lost heart muscle. Here, we used translating ribosome affinity …

Studies in the gravid rat model revealed a key role for the corpus luteal hormone, relaxin, in
the maternal circulatory changes of early pregnancy epitomized by profound systemic …

Patients admitted for acute heart failure (AHF) experience high rates of in‐hospital and post‐
discharge morbidity and mortality despite current therapies. Serelaxin is recombinant human …

Fibrosis refers to the hardening or scarring of tissues that usually results from aberrant
wound healing in response to organ injury, and its manifestations in various organs have …

Cardiovascular fibrosis refers to the scar tissue that develops in the injured heart and blood
vessels from an aberrant wound healing response to organ injury or insult. Established …

Abstract Relaxin, insulin-like peptide 3 (INSL3), relaxin-3, and INSL5 are the cognate
ligands for the relaxin family peptide (RXFP) receptors 1–4, respectively. RXFP1 activates …