Recent progress in psychiatric genetics—some hope but no hype

SF Stoltenberg, M Burmeister - Human molecular genetics, 2000 - academic.oup.com
The reputation of the field of psychiatric genetics has recently become tarnished in the view
of many human geneticists. Too many linked loci were claimed and withdrawn, too many …

Trinucleotide repeat expansion and neuropsychiatric disease

RL Margolis, MG McInnis, A Rosenblatt… - Archives of general …, 1999 - jamanetwork.com
Trinucleotide, or triplet, repeats consist of 3 nucleotides consecutively repeated (eg, CCG
CCG CCG CCG CCG) within a region of DNA, a not uncommon motif in the genome of …

Analysis of 14 CAG repeat‐containing genes in schizophrenia

R Joober, C Benkelfat, A Toulouse… - American journal of …, 1999 - Wiley Online Library
Recently, it has been suggested that trinucleotide repeat‐containing genes may be involved
in the etiology of schizophrenia. This study was aimed at investigating putative associations …

The unstable trinucleotide repeat story of major psychosis

JB Vincent, AD Paterson, E Strong… - American journal of …, 2000 - Wiley Online Library
New hopes for cloning susceptibility genes for schizophrenia and bipolar affective disorder
followed the discovery of a novel type of DNA mutation, namely unstable DNA. One class of …

Association of CAG repeat loci on chromosome 22 with schizophrenia and bipolar disorder

Q Saleem, D Dash, C Gandhi, A Kishore… - Molecular …, 2001 - nature.com
Chromosome 22 has been implicated in schizophrenia and bipolar disorder in a number of
linkage, association and cytogenetic studies. Recent evidence has also implicated CAG …

Schizophrenia: a genetic perspective

BS Shastry - International journal of molecular …, 2002 - spandidos-publications.com
Schizophrenia is a complex neurodevelopmental disorder characterized by mental
dysfunction across multiple domains of the brain. It affects 1% of world's general population …

Anticipation and CAG• CTG repeat expansion in schizophrenia and bipolar affective disorder

MT Fortune, JL Kennedy, JB Vincent - Current Psychiatry Reports, 2003 - Springer
The genetic contribution to the etiologies of schizophrenia and bipolar affective disorder
(BPAD) has been considered for many decades, with twin, family, and adoption studies …

Genetic basis of schizophrenia: trinucleotide repeats an update

M Vaswani, S Kapur - Progress in Neuro-Psychopharmacology and …, 2001 - Elsevier
Recent developments in technologies permit systematic screening of the entire human
genome as a strategy for identification of susceptibility genes of small effect that influence …

Anticipation, imprinting, trinucleotide repeat expansions and psychoses

K Ohara - Progress in Neuro-Psychopharmacology and …, 2001 - Elsevier
Since 1991, approximately 20 trinucleotide repeat expansion type neurodegenerative
disorders have been reported. They are clinically characterized by anticipation, ie …