Secondary electron attachment-induced radiation damage to genetic materials

J Narayanan SJ, D Tripathi, P Verma, A Adhikary… - ACS …, 2023 - ACS Publications
Reactions of radiation-produced secondary electrons (SEs) with biomacromolecules (eg,
DNA) are considered one of the primary causes of radiation-induced cell death. In this …

Interaction of low-energy electrons with radiosensitizers

B Sedmidubská, J Kočišek - Physical Chemistry Chemical Physics, 2024 - pubs.rsc.org
We provide an experimentalist's perspective on the present state-of-the-art in the studies of
low-energy electron interactions with common radiosensitizers, including compounds used …

Pathways of the Dissociative Electron Attachment Observed in 5- and 6-Azidomethyluracil Nucleosides: Nitrogen (N2) Elimination vs Azide Anion (N3) Elimination

D Adjei, Y Reyes, A Kumar, S Ward… - The Journal of …, 2023 - ACS Publications
5-Azidomethyl-2′-deoxyuridine (5-AmdU, 1) has been successfully employed for the
metabolic labeling of DNA and fluorescent imaging of live cells. 5-AmdU also demonstrated …

Photochemical and Single Electron Transfer Generation of 2′-Deoxycytidin-N4-yl Radical from Oxime Esters

H Peng, S Vu, P Retes, S Ward, A Kumar… - The Journal of …, 2023 - ACS Publications
A 2′-deoxycytidin-N 4-yl radical (dC·), a strong oxidant that also abstracts hydrogen atoms
from carbon–hydrogen bonds, is produced in a variety of DNA damaging processes. We …

Low-Energy Electron Damage to Plasmid DNA in Thin Films: Dependence on Substrates, Surface Density, Charging, Environment, and Uniformity

X Chen, N Karmaker, P Cloutier, AD Bass… - The Journal of …, 2022 - ACS Publications
The interaction of low-energy electrons (LEEs) with DNA plays a significant role in the
mechanisms leading to biological damage induced by ionizing radiation, particularly in …

Effects of substituent and excess electron attachment on proton transfer between the radiosensitizer base pairs in aqueous solution

C Zhang, X Cui, Y Zhao, L Duan, X Zhang… - Journal of Molecular …, 2022 - Elsevier
We investigate the proton transfer reaction of radiosensitizing drugs 5-substituted thymine-
adenine (5XT-A, X= Br, OCN) in water solutions through the density functional theory (DFT) …

Electron Attachment to the Nucleobase Uracil in Diethylene Glycol: The Signature of a Doorway

J Narayanan SJ, P Verma, A Adhikary… - …, 2024 - Wiley Online Library
The cellular environment plays a significant role in low energy electron‐mediated radiation
damage to genetic materials. In this study, we have modeled the effect of the bulk medium …

Low energy electron interaction with citric acid: a local complex potential based time-dependent wavepacket study

S Kumar, HK Singh, HP Bhattacharyya… - Journal of Chemical …, 2023 - Springer
The resonant low-energy electron (LEE) induced scattering off biomolecules is proposed to
undergo dissociative electron attachment (DEA) as one of the favoured pathways. In the …