CAR T-cell therapy for patients with multiple myeloma: current evidence and challenges

MJ Rendo, JJ Joseph, LM Phan… - Blood and lymphatic …, 2022 - Taylor & Francis
The therapeutic landscape of multiple myeloma (MM) has benefited from an emergence of
novel therapies over the last decade. By inducing T-cell kill of target cancer cells, chimeric …

Current use of CAR T cells to treat multiple myeloma

RS Firestone, S Mailankody - Hematology, 2023 - ashpublications.org
Anti–B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapies
currently approved by the US Food and Drug Administration (FDA) have dramatically …

Second-line chimeric antigen receptor T-cell therapy in diffuse large B-cell lymphoma: a cost-effectiveness analysis

AH Kelkar, ERS Cliff, CA Jacobson… - Annals of Internal …, 2023 - acpjournals.org
Background: First-line treatment of diffuse large B-cell lymphoma (DLBCL) achieves durable
remission in approximately 60% of patients. In relapsed or refractory disease, only about …

Estimation of eligibility for and response to CAR-T therapy in the United States

A Haslam, TB Hoeg, V Prasad - Blood Advances, 2024 - ashpublications.org
Chimeric antigen receptor (CAR) T-cell (CAR-T) therapies genetically modify a person's own
T cells to bind to antigens expressed on cancer cells. 1, 2 CAR-T has generated sizable …

Innovation in BCMA CAR-T therapy: Building beyond the Model T

R Banerjee, SS Lee, AJ Cowan - Frontiers in Oncology, 2022 - frontiersin.org
Autologous chimeric antigen receptor T-cell (CAR-T) therapies targeting B-cell maturation
antigen (BCMA) have revolutionized the field of multiple myeloma in the same way that the …

The preclinical discovery and clinical development of ciltacabtagene autoleucel (Cilta-cel) for the treatment of multiple myeloma

I Strassl, K Podar - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Despite remarkable therapeutic advances over the last two decades, which
have resulted in dramatic improvements in patient survival, multiple myeloma (MM) is still …

Intent matters: Real-world applicability of idecabtagene vicleucel usage in the United States

R Chakraborty, S Al Hadidi - Journal of clinical oncology …, 2023 - pubmed.ncbi.nlm.nih.gov
Intent Matters: Real-World Applicability of Idecabtagene Vicleucel Usage in the United States
Intent Matters: Real-World Applicability of Idecabtagene Vicleucel Usage in the United States …

Obstacles to global implementation of CAR T cell therapy in myeloma and lymphoma

FJ Medina-Olivares, A Gómez-De León… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Chimeric Antigen Receptor T-cell (CAR-T) therapies are transforming the treatment of B-cell
lymphoproliferative disorders and multiple myeloma, yet global access challenges and …

CARTIFAN-1: Concerning fatal adverse events with global use of chimeric antigen receptor–T-cell therapy in multiple myeloma

S Al Hadidi, ERS Cliff - European Journal of Cancer, 2023 - ejcancer.com
The use of chimeric antigen receptro T-cell therapy all over (CAR-T)-cell therapy in multiple
myeloma (MM) showed early promising results in heavily pre-treated patient with limited …

CAR T cells in multiple myeloma: lessons learned

V Prasad - Nature Reviews Clinical Oncology, 2024 - nature.com
The question of whether chimeric antigen receptor (CAR) T cell therapies should be used in
earlier lines (after 1–2 prior lines of therapy) in patients with relapsed and/or refractory …