Anti–B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T-cell therapies currently approved by the US Food and Drug Administration (FDA) have dramatically …
AH Kelkar, ERS Cliff, CA Jacobson… - Annals of Internal …, 2023 - acpjournals.org
Background: First-line treatment of diffuse large B-cell lymphoma (DLBCL) achieves durable remission in approximately 60% of patients. In relapsed or refractory disease, only about …
Chimeric antigen receptor (CAR) T-cell (CAR-T) therapies genetically modify a person's own T cells to bind to antigens expressed on cancer cells. 1, 2 CAR-T has generated sizable …
R Banerjee, SS Lee, AJ Cowan - Frontiers in Oncology, 2022 - frontiersin.org
Autologous chimeric antigen receptor T-cell (CAR-T) therapies targeting B-cell maturation antigen (BCMA) have revolutionized the field of multiple myeloma in the same way that the …
I Strassl, K Podar - Expert Opinion on Drug Discovery, 2024 - Taylor & Francis
Introduction Despite remarkable therapeutic advances over the last two decades, which have resulted in dramatic improvements in patient survival, multiple myeloma (MM) is still …
Intent Matters: Real-World Applicability of Idecabtagene Vicleucel Usage in the United States Intent Matters: Real-World Applicability of Idecabtagene Vicleucel Usage in the United States …
FJ Medina-Olivares, A Gómez-De León… - Frontiers in …, 2024 - pmc.ncbi.nlm.nih.gov
Chimeric Antigen Receptor T-cell (CAR-T) therapies are transforming the treatment of B-cell lymphoproliferative disorders and multiple myeloma, yet global access challenges and …
The use of chimeric antigen receptro T-cell therapy all over (CAR-T)-cell therapy in multiple myeloma (MM) showed early promising results in heavily pre-treated patient with limited …
V Prasad - Nature Reviews Clinical Oncology, 2024 - nature.com
The question of whether chimeric antigen receptor (CAR) T cell therapies should be used in earlier lines (after 1–2 prior lines of therapy) in patients with relapsed and/or refractory …