Networking brainstem and basal ganglia circuits for movement

S Arber, RM Costa - Nature Reviews Neuroscience, 2022 - nature.com
The execution and learning of diverse movements involve neuronal networks distributed
throughout the nervous system. The brainstem and basal ganglia are key for processing …

Prediction signals in the cerebellum: beyond supervised motor learning

C Hull - elife, 2020 - elifesciences.org
While classical views of cerebellar learning have suggested that this structure predominantly
operates according to an error-based supervised learning rule to refine movements …

Reverse-translational identification of a cerebellar satiation network

AYT Low, N Goldstein, JR Gaunt, KP Huang… - Nature, 2021 - nature.com
The brain is the seat of body weight homeostasis. However, our inability to control the
increasing prevalence of obesity highlights a need to look beyond canonical feeding …

Anipose: A toolkit for robust markerless 3D pose estimation

P Karashchuk, KL Rupp, ES Dickinson, S Walling-Bell… - Cell reports, 2021 - cell.com
Quantifying movement is critical for understanding animal behavior. Advances in computer
vision now enable markerless tracking from 2D video, but most animals move in 3D. Here …

NINscope, a versatile miniscope for multi-region circuit investigations

A de Groot, BJG van den Boom, RM van Genderen… - Elife, 2020 - elifesciences.org
Miniaturized fluorescence microscopes (miniscopes) have been instrumental to monitor
neural signals during unrestrained behavior and their open-source versions have made …

Competition between parallel sensorimotor learning systems

ST Albert, J Jang, S Modchalingam, B Marius't Hart… - elife, 2022 - elifesciences.org
Sensorimotor learning is supported by at least two parallel systems: a strategic process that
benefits from explicit knowledge and an implicit process that adapts subconsciously. How do …

Purkinje cell microzones mediate distinct kinematics of a single movement

FGC Blot, JJ White, A van Hattem, L Scotti… - nature …, 2023 - nature.com
The classification of neuronal subpopulations has significantly advanced, yet its relevance
for behavior remains unclear. The highly organized flocculus of the cerebellum, known to …

Synchronous spiking of cerebellar Purkinje cells during control of movements

E Sedaghat-Nejad, JS Pi, P Hage… - Proceedings of the …, 2022 - National Acad Sciences
The ability of the brain to accurately control a movement depends on the cerebellum. Yet,
how the cerebellar neurons encode information relevant for this control remains poorly …

Diverse inhibitory projections from the cerebellar interposed nucleus

EN Judd, SM Lewis, AL Person - Elife, 2021 - elifesciences.org
The cerebellum consists of parallel circuit modules that contribute to diverse behaviors,
spanning motor to cognitive. Recent work employing cell-type-specific tracing has identified …

Disrupting cortico-cerebellar communication impairs dexterity

JZ Guo, BA Sauerbrei, JD Cohen, M Mischiati… - Elife, 2021 - elifesciences.org
To control reaching, the nervous system must generate large changes in muscle activation
to drive the limb toward the target, and must also make smaller adjustments for precise and …