Human malignancies arise predominantly in tissues of epithelial origin, where the stepwise
transformation from healthy epithelium to premalignant dysplasia to invasive neoplasia …

Many drugs that target transforming growth factor-β (TGFβ) signalling have been developed,
some of which have reached Phase III clinical trials for a number of disease applications …

Inflammasome complexes function as key innate immune effectors that trigger inflammation
in response to pathogen-and danger-associated signals. Here, we report that germline …

Genes in which germline mutations confer highly or moderately increased risks of cancer
are called cancer predisposition genes. More than 100 of these genes have been identified …

Human genetics research has discovered thousands of proteins associated with complex
and rare diseases. Genome-wide association studies (GWAS) and studies of Mendelian …

Transforming growth factor-β (TGF-β) is widely recognized as a core pathway of fibrosis.
Inhibition of TGF-β signaling may thus offer potential for antifibrotic therapies. Long-term …

Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and are
a major cause of cancer mortality. These highly heterogeneous tumors arise from closely …

Purpose: This study examined the feasibility, efficacy (abscopal effect), and immune effects
of TGFβ blockade during radiotherapy in metastatic breast cancer patients. Experimental …

Background In advanced cancers, transforming growth factor-beta (TGFβ) promotes tumor
growth and metastases and suppresses host antitumor immunity. GC1008 is a human anti …

Introduction The safety and efficacy of bintrafusp alfa, a first-in-class bifunctional fusion
protein composed of the extracellular domain of the transforming growth factor β (TGF-β) …