Oxidative stress: A major pathogenesis and potential therapeutic target of antioxidative agents in Parkinson's disease and Alzheimer's disease

T Jiang, Q Sun, S Chen - Progress in neurobiology, 2016 - Elsevier
Oxidative stress reflects an imbalance between the overproduction and incorporation of free
radicals and the dynamic ability of a biosystem to detoxify reactive intermediates. Free …

Nrf2–ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases

I Buendia, P Michalska, E Navarro, I Gameiro… - Pharmacology & …, 2016 - Elsevier
Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …

Senile osteoporosis: the involvement of differentiation and senescence of bone marrow stromal cells

A Qadir, S Liang, Z Wu, Z Chen, L Hu… - International journal of …, 2020 - mdpi.com
Senile osteoporosis has become a worldwide bone disease with the aging of the world
population. It increases the risk of bone fracture and seriously affects human health. Unlike …

ROS and brain diseases: the good, the bad, and the ugly

A Popa-Wagner, S Mitran, S Sivanesan… - Oxidative medicine …, 2013 - Wiley Online Library
The brain is a major metabolizer of oxygen and yet has relatively feeble protective
antioxidant mechanisms. This paper reviews the Janus‐faced properties of reactive oxygen …

Natural compounds against doxorubicin‐induced cardiotoxicity: a review on the involvement of Nrf2/ARE signaling pathway

F Yarmohammadi, R Rezaee… - Phytotherapy Research, 2021 - Wiley Online Library
Cardiotoxicity is the main concern for long‐term use of the doxorubicin (DOX). Reactive
oxygen species (ROS) generation leads to oxidative stress that significantly contributes to …

Potential role of olive oil phenolic compounds in the prevention of neurodegenerative diseases

J Rodríguez-Morató, L Xicota, M Fitó, M Farré… - Molecules, 2015 - mdpi.com
Adherence to the Mediterranean Diet (MD) has been associated with a reduced incidence of
neurodegenerative diseases and better cognitive performance. Virgin olive oil, the main …

Senescence of mesenchymal stem cells

Y Li, Q Wu, Y Wang, L Li, H Bu… - … journal of molecular …, 2017 - spandidos-publications.com
Mesenchymal stem cells (MSCs) have been used in cell-based therapy for various diseases,
due to their immunomodulatory and inflammatory effects. However, the function of MSCs is …

[图书][B] Nutraceuticals: efficacy, safety and toxicity

RC Gupta, R Lall, A Srivastava - 2021 - books.google.com
Nutraceuticals: Efficacy, Safety and Toxicity, Second Edition, brings together everything that
is currently known about nutraceuticals and their potential toxic effects. The book introduces …

Dimethyl fumarate, a two‐edged drug: current status and future directions

NEB Saidu, N Kavian, K Leroy, C Jacob… - Medicinal research …, 2019 - Wiley Online Library
Dimethyl fumarate (DMF) is a fumaric acid ester registered for the treatment of relapsing‐
remitting multiple sclerosis (RRMS). It induces protein succination leading to inactivation of …

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases

G Morris, M Berk, AF Carvalho, M Maes… - Behavioural brain …, 2018 - Elsevier
Ferroptosis is a unique form of programmed death, characterised by cytosolic accumulation
of iron, lipid hydroperoxides and their metabolites, and effected by the fatal peroxidation of …