Regulation and functions of non-m6A mRNA modifications
Nucleobase modifications are prevalent in eukaryotic mRNA and their discovery has
resulted in the emergence of epitranscriptomics as a research field. The most abundant …
resulted in the emergence of epitranscriptomics as a research field. The most abundant …
Precision RNA base editing with engineered and endogenous effectors
LS Pfeiffer, T Stafforst - Nature Biotechnology, 2023 - nature.com
RNA base editing refers to the rewriting of genetic information within an intact RNA molecule
and serves various functions, such as evasion of the endogenous immune system and …
and serves various functions, such as evasion of the endogenous immune system and …
N1-methylpseudouridylation of mRNA causes +1 ribosomal frameshifting
In vitro-transcribed (IVT) mRNAs are modalities that can combat human disease, exemplified
by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
by their use as vaccines for severe acute respiratory syndrome coronavirus 2 (SARS-CoV …
Novel insight into the regulatory roles of diverse RNA modifications: Re-defining the bridge between transcription and translation
H Shi, P Chai, R Jia, X Fan - Molecular cancer, 2020 - Springer
RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …
necessary reactions, and these modifications play roles in essential molecular mechanisms …
RNA editing: Expanding the potential of RNA therapeutics
RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …
rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic …
New twists in detecting mRNA modification dynamics
Modified nucleotides in mRNA are an essential addition to the standard genetic code of four
nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics …
nucleotides in animals, plants, and their viruses. The emerging field of epitranscriptomics …
Genome-wide quantification of ADAR adenosine-to-inosine RNA editing activity
SH Roth, EY Levanon, E Eisenberg - Nature methods, 2019 - nature.com
Abstract Adenosine-to-inosine (A-to-I) RNA editing by the adenosine deaminase that acts on
RNA (ADAR) enzymes is a common RNA modification, preventing false activation of the …
RNA (ADAR) enzymes is a common RNA modification, preventing false activation of the …
ADAR RNA modifications, the epitranscriptome and innate immunity
Modified bases act as marks on cellular RNAs so that they can be distinguished from foreign
RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations …
RNAs, reducing innate immune responses to endogenous RNA. In humans, mutations …
Pseudouridinylation of mRNA coding sequences alters translation
DE Eyler, MK Franco, Z Batool, MZ Wu… - Proceedings of the …, 2019 - National Acad Sciences
Chemical modifications of RNAs have long been established as key modulators of
nonprotein-coding RNA structure and function in cells. There is a growing appreciation that …
nonprotein-coding RNA structure and function in cells. There is a growing appreciation that …
[HTML][HTML] Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors
RNA editing is a process by which post-transcriptional changes of mRNA nucleotides alter
protein function through modification of the amino acid content. The 5HT 2C serotonin …
protein function through modification of the amino acid content. The 5HT 2C serotonin …