In recent years, sensory neuroscientists have made major efforts to dissect the structure and
function of ribbon synapses which process sensory information in the eye and ear. This …

The synapsins are a family of neuronal phosphoproteins evolutionarily conserved in
invertebrate and vertebrate organisms. Their best-characterised function is to modulate …

Photoreceptor cells utilize ribbon synapses to transmit sensory signals at high resolution.
Ribbon synapses release neurotransmitters tonically, with a high release rate made …

Synapses are not static; their performance is modified adaptively in response to activity.
Presynaptic mechanisms that affect the probability of transmitter release or the amount of …

The synaptic vesicle glycoprotein 2 (SV2) family is comprised of three paralogues: SV2A,
SV2B, and SV2C. In vertebrates, SV2s are 12-transmembrane proteins present on every …

The molecular organization of ribbon synapses in photoreceptors and ON bipolar cells is
reviewed in relation to the process of neurotransmitter release. The interactions between …

We describe here the identification and molecular characterization of a new brain protein
that we named SV2C because it is homologous to the synaptic vesicle proteins SV2A and …

Phase separation in the cytoplasm is emerging as a major principle in intracellular
organization. In this process, sets of macromolecules assemble themselves into liquid …

Vesicular transporters regulate the amount and type of neurotransmitter sequestered into
synaptic vesicles and, hence, the kind of signal transmitted to postsynaptic neurons …

In this review we describe some of the remarkable and intricate mechanisms through which
the calcium ion (Ca 2+) contributes to detection, transduction and synaptic transfer of light …