Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …

Human Islet amyloid polypeptide (hIAPP) from pancreatic β cells in the islet of Langerhans
has different physiological functions including inhibiting the release of insulin and glucagon …

Polyphenolic compounds are thought to show considerable promise for the treatment of
various metabolic disorders, including type 2 diabetes mellitus (T2DM). This review …

Although no single animal model replicates all aspects of diabetes mellitus in humans,
animal models are essential for the study of energy balance and metabolism control as well …

β-cell death is regarded as a major event driving loss of insulin secretion and hyperglycemia
in both type 1 and type 2 diabetes mellitus. In this review, we explore past, present, and …

There are over 40 identified human disorders that involve certain proteins folding incorrectly,
accumulating in the body causing damage to cells and organs and causing disease. Type 2 …

Loss of pancreatic β-cell mass is deleterious for type 2 diabetes patients since it reduces
insulin production, critical for glucose homeostasis. The main research axis developed over …

Objective Aggregation of human islet amyloid polypeptide (hIAPP), a β-cell secretory
product, leads to islet amyloid deposition, islet inflammation and β-cell loss in type 2 …

Cases of Type 2 Diabetes Mellitus (T2DM) are increasing at an alarming rate due to the rise
in obesity, sedentary lifestyles, glucose-rich diets and other factors. Numerous studies have …

Type 2 diabetes mellitus is a progressive disease that is characterized by the appearance of
insulin resistance. The term insulin resistance is very wide and could affect different proteins …