Biomedical engineer's guide to the clinical aspects of intensive care mechanical ventilation
Background Mechanical ventilation is an essential therapy to support critically ill respiratory
failure patients. Current standards of care consist of generalised approaches, such as the …
failure patients. Current standards of care consist of generalised approaches, such as the …
Paradoxical and bidirectional drug effects
SW Smith, M Hauben, JK Aronson - Drug safety, 2012 - Springer
A paradoxical drug reaction constitutes an outcome that is opposite from the outcome that
would be expected from the drug's known actions. There are three types: 1 A paradoxical …
would be expected from the drug's known actions. There are three types: 1 A paradoxical …
Virtual patients for mechanical ventilation in the intensive care unit
Background Mechanical ventilation (MV) is a core intensive care unit (ICU) therapy.
Significant inter-and intra-patient variability in lung mechanics and condition makes …
Significant inter-and intra-patient variability in lung mechanics and condition makes …
Time-varying respiratory system elastance: a physiological model for patients who are spontaneously breathing
Background Respiratory mechanics models can aid in optimising patient-specific
mechanical ventilation (MV), but the applications are limited to fully sedated MV patients …
mechanical ventilation (MV), but the applications are limited to fully sedated MV patients …
Over-distension prediction via hysteresis loop analysis and patient-specific basis functions in a virtual patient model
Background and objective Recruitment maneuvers (RMs) with subsequent positive-end-
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …
expiratory-pressure (PEEP) have proven effective in recruiting lung volume and preventing …
Prediction of lung mechanics throughout recruitment maneuvers in pressure-controlled ventilation
Mechanical ventilation (MV) is a core therapy in the intensive care unit (ICU). Some patients
rely on MV to support breathing. However, it is a difficult therapy to optimise, where inter-and …
rely on MV to support breathing. However, it is a difficult therapy to optimise, where inter-and …
Exposure to aldehyde cherry e-liquid flavoring and its vaping byproduct disrupt pulmonary surfactant biophysical function
A Martin, C Tempra, Y Yu, J Liekkinen… - Environmental …, 2024 - ACS Publications
Over the past decade, there has been a significant rise in the use of vaping devices,
particularly among adolescents, raising concerns for effects on respiratory health …
particularly among adolescents, raising concerns for effects on respiratory health …
Whole-lung finite-element models for mechanical ventilation and respiratory research applications
N Avilés-Rojas, DE Hurtado - Frontiers in Physiology, 2022 - frontiersin.org
Mechanical ventilation has been a vital treatment for Covid-19 patients with respiratory
failure. Lungs assisted with mechanical ventilators present a wide variability in their …
failure. Lungs assisted with mechanical ventilators present a wide variability in their …
Prediction and estimation of pulmonary response and elastance evolution for volume-controlled and pressure-controlled ventilation
Mechanical ventilation (MV) is a core treatment for patients suffering from respiratory
disease and failure. However, MV settings are not standardized due to significant inter-and …
disease and failure. However, MV settings are not standardized due to significant inter-and …
Surfactant proteins SP-B and SP-C in pulmonary surfactant monolayers: Physical properties controlled by specific protein–lipid interactions
J Liekkinen, A Olzynska, L Cwiklik… - Langmuir, 2023 - ACS Publications
The lining of the alveoli is covered by pulmonary surfactant, a complex mixture of surface-
active lipids and proteins that enables efficient gas exchange between inhaled air and the …
active lipids and proteins that enables efficient gas exchange between inhaled air and the …