Transcription through the nucleosome
T Kujirai, H Kurumizaka - Current Opinion in Structural Biology, 2020 - Elsevier
Highlights•Dynamic changes in the nucleosome structure take place when RNA polymerase
II transcribes through a nucleosome.•Nucleosome reassembly may be mediated by the …
II transcribes through a nucleosome.•Nucleosome reassembly may be mediated by the …
Structure and function of the histone chaperone FACT–Resolving FACTual issues
Abstract FAcilitates Chromatin Transcription (FACT) has been considered essential for
transcription through chromatin mostly based on cell-free experiments. However, FACT …
transcription through chromatin mostly based on cell-free experiments. However, FACT …
The impact of proinflammatory cytokines on the β-cell regulatory landscape provides insights into the genetics of type 1 diabetes
M Ramos-Rodríguez, H Raurell-Vila, ML Colli… - Nature …, 2019 - nature.com
The early stages of type 1 diabetes (T1D) are characterized by local autoimmune
inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show …
inflammation and progressive loss of insulin-producing pancreatic β cells. Here we show …
FACT regulates pluripotency through proximal and distal regulation of gene expression in murine embryonic stem cells
Background The FACT complex is a conserved histone chaperone with critical roles in
transcription and histone deposition. FACT is essential in pluripotent and cancer cells, but …
transcription and histone deposition. FACT is essential in pluripotent and cancer cells, but …
SMARCAD1 is an ATP-dependent histone octamer exchange factor with de novo nucleosome assembly activity
The adenosine 5′-triphosphate (ATP)–dependent chromatin remodeler SMARCAD1 acts
on nucleosomes during DNA replication, repair, and transcription, but despite its implication …
on nucleosomes during DNA replication, repair, and transcription, but despite its implication …
Structural visualization of key steps in nucleosome reorganization by human FACT
K Mayanagi, K Saikusa, N Miyazaki, S Akashi… - Scientific reports, 2019 - nature.com
Facilitates chromatin transcription (FACT) is a histone chaperone, which accomplishes both
nucleosome assembly and disassembly. Our combined cryo-electron microscopy (EM) and …
nucleosome assembly and disassembly. Our combined cryo-electron microscopy (EM) and …
The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states
M Murawska, RA Greenstein, T Schauer, KCF Olsen… - Cell reports, 2021 - cell.com
Heterochromatin formation requires three distinct steps: nucleation, self-propagation
(spreading) along the chromosome, and faithful maintenance after each replication cycle …
(spreading) along the chromosome, and faithful maintenance after each replication cycle …
Cockayne syndrome B protein acts as an ATP-dependent processivity factor that helps RNA polymerase II overcome nucleosome barriers
While loss-of-function mutations in Cockayne syndrome group B protein (CSB) cause
neurological diseases, this unique member of the SWI2/SNF2 family of chromatin …
neurological diseases, this unique member of the SWI2/SNF2 family of chromatin …
Arabidopsis CHROMATIN REMODELING 19 acts as a transcriptional repressor and contributes to plant pathogen resistance
H Kang, Y Liu, T Fan, J Ma, D Wu, T Heitz… - The Plant …, 2022 - academic.oup.com
Chromatin remodelers act in an ATP-dependent manner to modulate chromatin structure
and thus genome function. Here, we report that the Arabidopsis (Arabidopsis thaliana) …
and thus genome function. Here, we report that the Arabidopsis (Arabidopsis thaliana) …
The chaperone FACT and histone H2B ubiquitination maintain S. pombe genome architecture through genic and subtelomeric functions
M Murawska, T Schauer, A Matsuda, MD Wilson… - Molecular cell, 2020 - cell.com
The histone chaperone FACT and histone H2B ubiquitination (H2Bub) facilitate RNA
polymerase II (Pol II) passage through chromatin, yet it is not clear how they cooperate …
polymerase II (Pol II) passage through chromatin, yet it is not clear how they cooperate …