ABC transporters are essential for cellular physiology. Humans have 48 ABC genes
organized into seven distinct families. Of these genes, 44 (in five distinct families) encode for …

ATP-binding cassette (ABC) transporters constitute one of the largest and most ancient
protein superfamilies found in all living organisms. They function as molecular machines by …

Carnitine is essential for the transfer of long-chain fatty acids across the inner mitochondrial
membrane for subsequent β-oxidation. It can be synthesized by the body or assumed with …

Peroxisomes are dynamic organelles that play an essential role in a variety of cellular
catabolic and anabolic metabolic pathways, including fatty acid alpha-and beta-oxidation …

Peroxisomes are often dismissed as the cellular hoi polloi, relegated to cleaning up reactive
oxygen chemical debris discarded by other organelles. However, their functions extend far …

Abstract X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder.
The disease is caused by mutations in the ABCD1 gene that encodes the peroxisomal …

ABC transporters constitute one of the largest protein families found in all living organisms.
ABC transporters are driven by ATP hydrolysis and can act as exporters as well as …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

X-Linked adrenoleukodystrophy (ALD) is a peroxisomal metabolic disorder with a highly
complex clinical presentation. ALD is caused by mutations in the ABCD1 gene, which leads …

Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of
double bonds. FAs with C> 20 are called very long-chain fatty acids (VLCFAs). VLCFAs are …