The liver is an organ that is particularly exposed to reactive oxygen species (ROS), which
not only arise during metabolic functions but also during the biotransformation of …

In the human body, almost all cells interact with extracellular matrices (ECMs), which have
tissue and organ-specific compositions and architectures. These ECMs not only function as …

The recent demonstration that primary cells from the liver can be expanded in vitro as
organoids holds enormous promise for regenerative medicine and disease modelling. The …

Chronic liver diseases, characterized by an excessive accumulation of extracellular matrix
(ECM) resulting in scar tissue formation, are a growing health problem causing increasing …

From embryonic development, postnatal growth and adult homeostasis to reparative and
disease states, cells and tissues undergo constant changes in genome activity, cell fate …

Extensive research has been carried out during the last few decades, providing a detailed
account of thousands of discovered phytochemicals and their biological activities that have …

Hepatic fibrosis is a dynamic process that occurs as a wound healing response against liver
injury. During fibrosis, crosstalk between parenchymal and non-parenchymal cells …

Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive storage of fatty acids
in the form of triglycerides in hepatocytes. It is most prevalent in western countries and …

Human whole-liver perfusion-decellularization is an emerging technique for producing bio-
scaffolds for tissue engineering purposes. The native liver extracellular matrix (ECM) …

Nonalcoholic fatty liver disease prevalence is soaring with the obesity pandemic, but the
pathogenic mechanisms leading to the progression toward active nonalcoholic …