TRPV4: molecular conductor of a diverse orchestra
Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …
TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease
Crosstalk between ion channels and small GTPases is critical during homeostasis and
disease, but little is known about the structural underpinnings of these interactions. TRPV4 is …
disease, but little is known about the structural underpinnings of these interactions. TRPV4 is …
TRPV4: a physio and pathophysiologically significant ion channel
T Rosenbaum, M Benítez-Angeles… - International journal of …, 2020 - mdpi.com
Transient Receptor Potential (TRP) channels are a family of ion channels whose members
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …
are distributed among all kinds of animals, from invertebrates to vertebrates. The importance …
TRPing to the point of clarity: understanding the function of the complex TRPV4 ion channel
TL Toft-Bertelsen, N MacAulay - Cells, 2021 - mdpi.com
The transient receptor potential vanilloid 4 channel (TRPV4) belongs to the mammalian TRP
superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate …
superfamily of cation channels. TRPV4 is ubiquitously expressed, activated by a disparate …
Combined NGS Approaches Identify Mutations in the Intraflagellar Transport Gene IFT140 in Skeletal Ciliopathies with Early Progressive Kidney Disease
M Schmidts, V Frank, T Eisenberger, S Al Turki… - Human …, 2013 - Wiley Online Library
Ciliopathies are genetically heterogeneous disorders characterized by variable expressivity
and overlaps between different disease entities. This is exemplified by the short rib …
and overlaps between different disease entities. This is exemplified by the short rib …
Mutations in TRPV4 cause an inherited arthropathy of hands and feet
SR Lamandé, Y Yuan, IL Gresshoff, L Rowley… - Nature …, 2011 - nature.com
Familial digital arthropathy-brachydactyly (FDAB) is a dominantly inherited condition that is
characterized by aggressive osteoarthropathy of the fingers and toes and consequent …
characterized by aggressive osteoarthropathy of the fingers and toes and consequent …
Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A–mediated phosphorylation
Transient receptor potential vanilloid 4 (TRPV4) is a Ca 2+-permeable channel of the
transient receptor potential (TRP) superfamily activated by diverse stimuli, including warm …
transient receptor potential (TRP) superfamily activated by diverse stimuli, including warm …
TRPV4‐associated skeletal dysplasias
G Nishimura, E Lausch, R Savarirayan… - American Journal of …, 2012 - Wiley Online Library
Dominant mutations in the TRPV4 gene result in a bone dysplasia family and form a
continuous phenotypic spectrum that includes, in decreasing severity, lethal, and nonlethal …
continuous phenotypic spectrum that includes, in decreasing severity, lethal, and nonlethal …
Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel
The TRPV4 calcium-permeable cation channel plays important physiological roles in
osmosensation, mechanosensation, cell barrier formation, and bone homeostasis. Recent …
osmosensation, mechanosensation, cell barrier formation, and bone homeostasis. Recent …