The current opioid epidemic is one of the most severe public health crisis in US history.
Responding to it has been difficult due to its rapidly changing nature and the severity of its …

The opioid crisis constitutes a public health challenge at the intersection of two interrelated
medical problems—opioid addiction and chronic pain. Overlap of the reward and pain …

Substituted fentanyls are abused and cause rapid fatal overdose. As their pharmacology is
not well characterized, we examined in vitro pharmacology and structure–activity …

Background Intercostal nerve cryoablation (INCA) coupled with surgical stabilization of rib
fractures (SSRF) has been shown to reduce post-operative pain scores but at what monetary …

Patient access to mindfulness-based stress reduction (MBSR), a complementary and
integrative health approach that is proven to reduce chronic pain, can be increased via …

The nucleus accumbens (NAc) and the ventral tegmental area (VTA) are critical hubs in the
brain circuitry controlling chronic pain. Yet, how these 2 regions interact to shape the chronic …

Objective: To investigate the effect of crocin carotenoid on BNDF and CREB gene
expression in the brain ventral tegmental area (VTA) and the serum level of BDNF in …

Introduction Sternal fractures are debilitating due to intractable pain, constant fracture
movement and limited range of motion (ROM) of the upper extremities (UE). Traditional …

Background Integrated primary care programs for patients living with chronic pain which are
accessible, interdisciplinary, and patient-centered are needed for preventing chronicity and …

Abstract In early April 2018, Dr. Maria Oquendo, President of the American Psychiatric
Association, and Dr. Nora Volkow, Director of the National Institute on Drug Abuse …