Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by Kerschbaum, 1 interest in
macrocyclic lactones, defined as lactones with more than 8 atoms in the ring, has been …

1. INTRODUCTION Ever since the first isolation of Exaltolide 1 (Figure 1) in 1927 by
Kerschbaum, 1 interest in macrocyclic lactones, defined as lactones with more than 8 atoms …

Supported total synthesis: The combinatorial synthesis of a 122-membered macrosphelide
library including macrosphelides A, C, E, and F (see picture) has been achieved based on a …

An efficient protocol for the preparation of MOM ethers from alcohols and formaldehyde
dimethyl acetal (DMFA) using ZrCl4 (10mol%) at room temperature under solvent free …

Unified and highly convergent total syntheses of (+)-macrosphelides A and B are described.
Key features of the syntheses include (1) concise synthesis of the optically active δ-hydroxy …

Hybrid compounds of macrosphelides and epothilones, both of which are natural macrolides
having a 16-membered skeleton, were designed and synthesized using a ring-closing …

A new total synthesis of macrosphelides A and B using ring-closing metathesis (RCM) as a
macrocyclization step is described. The substrate of the RCM could be synthesized from …

Studies directed toward the synthesis of acremodiol and acremonol resulted in the synthesis
of two macrodiolides 1, 1a, and 2 besides 3. The attempted synthesis of 1 and 2 confirmed …

A new synthetic route for macrosphelides A, B, and E based on ring-closing metathesis
(RCM) was established. The substrates for RCM could be synthesized starting from …

A stereoselective synthesis of verbalactone—determination of absolute stereochemistry -
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