The “neuro-glial-vascular” unit: the role of glia in neurovascular unit formation and dysfunction

EC Kugler, J Greenwood… - Frontiers in Cell and …, 2021 - frontiersin.org
The neurovascular unit (NVU) is a complex multi-cellular structure consisting of endothelial
cells (ECs), neurons, glia, smooth muscle cells (SMCs), and pericytes. Each component is …

The pathophysiology of geographic atrophy secondary to age-related macular degeneration and the complement pathway as a therapeutic target

DS Boyer, U Schmidt-Erfurth… - Retina, 2017 - journals.lww.com
Purpose: Geographic atrophy (GA) is an advanced, vision-threatening form of age-related
macular degeneration (AMD) affecting approximately five million individuals worldwide. To …

[HTML][HTML] Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: a randomized phase 2 trial

DS Liao, FV Grossi, D El Mehdi, MR Gerber, DM Brown… - Ophthalmology, 2020 - Elsevier
Purpose Geographic atrophy (GA), a late stage of age-related macular degeneration (AMD),
is a major cause of blindness. Even while central visual acuity remains relatively well …

Oxidative stress and antioxidants in age-related macular degeneration

N Kushwah, K Bora, M Maurya, MC Pavlovich, J Chen - Antioxidants, 2023 - mdpi.com
Oxidative stress plays a crucial role in aging-related eye diseases, including age-related
macular degeneration (AMD), cataracts, and glaucoma. With age, antioxidant reparative …

Retina in a dish: Cell cultures, retinal explants and animal models for common diseases of the retina

S Schnichels, F Paquet-Durand, M Löscher… - Progress in retinal and …, 2021 - Elsevier
For many retinal diseases, including age-related macular degeneration (AMD), glaucoma,
and diabetic retinopathy (DR), the exact pathogenesis is still unclear. Moreover, the currently …

Central role of oxidative stress in age‐related macular degeneration: evidence from a review of the molecular mechanisms and animal models

S Abokyi, CH To, TT Lam, DY Tse - Oxidative medicine and …, 2020 - Wiley Online Library
Age‐related macular degeneration (AMD) is a common cause of visual impairment in the
elderly. There are very limited therapeutic options for AMD with the predominant therapies …

[HTML][HTML] A new perspective on lipid research in age-related macular degeneration

EM van Leeuwen, E Emri, BMJ Merle, JM Colijn… - Progress in retinal and …, 2018 - Elsevier
There is an urgency to find new treatment strategies that could prevent or delay the onset or
progression of AMD. Different classes of lipids and lipoproteins metabolism genes have …

Animal models of age related macular degeneration

ME Pennesi, M Neuringer, RJ Courtney - Molecular aspects of medicine, 2012 - Elsevier
Age related macular degeneration (AMD) is the leading cause of vision loss of those over
the age of 65 in the industrialized world. The prevalence and need to develop effective …

[HTML][HTML] Dry age-related macular degeneration: mechanisms, therapeutic targets, and imaging

CB Rickman, S Farsiu, CA Toth… - … ophthalmology & visual …, 2013 - jov.arvojournals.org
Age-related macular degeneration is the leading cause of irreversible visual dysfunction in
individuals over 65 in Western Society. Patients with AMD are classified as having early …

RPE necroptosis in response to oxidative stress and in AMD

J Hanus, C Anderson, S Wang - Ageing research reviews, 2015 - Elsevier
Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in
the elderly. The underlying mechanism of non-neovascular AMD (dry AMD), also named …