Roles of indole as an interspecies and interkingdom signaling molecule

JH Lee, TK Wood, J Lee - Trends in microbiology, 2015 - cell.com
A number of bacteria, and some plants, produce large quantities of indole, which is
widespread in animal intestinal tracts and in the rhizosphere. Indole, as an interspecies and …

Metabolites of microbiota response to tryptophan and intestinal mucosal immunity: A therapeutic target to control intestinal inflammation

J Zhang, S Zhu, N Ma, LJ Johnston… - Medicinal Research …, 2021 - Wiley Online Library
In a complex, diverse intestinal environment, commensal microbiota metabolizes excessive
dietary tryptophan to produce more bioactive metabolites connecting with kinds of diverse …

Acinetobacter species as model microorganisms in environmental microbiology: current state and perspectives

J Jung, W Park - Applied microbiology and biotechnology, 2015 - Springer
Acinetobacter occupies an important position in nature because of its ubiquitous presence in
diverse environments such as soils, fresh water, oceans, sediments, and contaminated sites …

Indole: a signaling molecule or a mere metabolic byproduct that alters bacterial physiology at a high concentration?

J Kim, W Park - Journal of Microbiology, 2015 - Springer
Indole is an organic compound that is widespread in microbial communities inhabiting
diverse habitats, like the soil environment and human intestines. Measurement of indole …

Combatting bacterial persister cells

TK Wood - Biotechnology and bioengineering, 2016 - Wiley Online Library
Most bacterial cells lead lives of quiet desperation in biofilms, combatting stress; yet, their
prevalence attests to their ability to alter gene regulation to cope with myriad insults. Since …

Probiotic Escherichia coli inhibits biofilm formation of pathogenic E. coli via extracellular activity of DegP

K Fang, X Jin, SH Hong - Scientific reports, 2018 - nature.com
Many chronic infections involve bacterial biofilms, which are difficult to eliminate using
conventional antibiotic treatments. Biofilm formation is a result of dynamic intra-or inter …

Persistent persister misperceptions

JS Kim, TK Wood - Frontiers in microbiology, 2016 - frontiersin.org
Persister cells survive antibiotic treatment due to their lack of metabolism, rather than
through genetic change, as shown via four seminal experiments conducted by the …

Exploiting rhizosphere microbial cooperation for developing sustainable agriculture strategies

Y Besset-Manzoni, L Rieusset, P Joly, G Comte… - … Science and Pollution …, 2018 - Springer
The rhizosphere hosts a considerable microbial community. Among that community, bacteria
called plant growth-promoting rhizobacteria (PGPR) can promote plant growth and defense …

Antibiofilm and Antivirulence Properties of Indoles Against Serratia marcescens

S Sethupathy, E Sathiyamoorthi, YG Kim… - Frontiers in …, 2020 - frontiersin.org
Indole and its derivatives have been shown to interfere with the quorum sensing (QS)
systems of a wide range of bacterial pathogens. While indole has been previously shown to …

Screening of natural product derivatives identifies two structurally related flavonoids as potent quorum sensing inhibitors against gram-negative bacteria

S Manner, A Fallarero - International journal of molecular sciences, 2018 - mdpi.com
Owing to the failure of conventional antibiotics in biofilm control, alternative approaches are
urgently needed. Inhibition of quorum sensing (QS) represents an attractive target since it is …