[HTML][HTML] Dopaminergic neurons and brain reward pathways: from neurogenesis to circuit assembly
Midbrain dopaminergic (DA) neurons in the substantia nigra pars compacta and ventral
tegmental area regulate extrapyramidal movement and important cognitive functions …
tegmental area regulate extrapyramidal movement and important cognitive functions …
Ski and SnoN, potent negative regulators of TGF-β signaling
J Deheuninck, K Luo - Cell research, 2009 - nature.com
Ski and the closely related SnoN were discovered as oncogenes by their ability to transform
chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and …
chicken embryo fibroblasts upon overexpression. While elevated expressions of Ski and …
p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug
SP Wang, WL Wang, YL Chang, CT Wu, YC Chao… - Nature cell …, 2009 - nature.com
The tumour suppressor p53 is known to prevent cancer progression by inhibiting
proliferation and inducing apoptosis of tumour cells. Slug, an invasion promoter, exerts its …
proliferation and inducing apoptosis of tumour cells. Slug, an invasion promoter, exerts its …
Transcriptional cofactors Ski and SnoN are major regulators of the TGF-β/Smad signaling pathway in health and disease
AC Tecalco-Cruz, DG Ríos-López… - Signal transduction and …, 2018 - nature.com
The transforming growth factor-β (TGF-β) family plays major pleiotropic roles by regulating
many physiological processes in development and tissue homeostasis. The TGF-β signaling …
many physiological processes in development and tissue homeostasis. The TGF-β signaling …
[HTML][HTML] TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel
Transient receptor potential (TRP) channels, a superfamily of ion channels, can be divided
into 7 subfamilies, including TRPV, TRPC, TRPP, and 4 others. Functional TRP channels …
into 7 subfamilies, including TRPV, TRPC, TRPP, and 4 others. Functional TRP channels …
Wnt-1 signal induces phosphorylation and degradation of c-Myb protein via TAK1, HIPK2, and NLK
C Kanei-Ishii, J Ninomiya-Tsuji, J Tanikawa… - Genes & …, 2004 - genesdev.cshlp.org
The c-myb proto-oncogene product (c-Myb) regulates both the proliferation and apoptosis of
hematopoietic cells by inducing the transcription of a group of target genes. However, the …
hematopoietic cells by inducing the transcription of a group of target genes. However, the …
Axin stimulates p53 functions by activation of HIPK2 kinase through multimeric complex formation
Axin and p53 are tumor suppressors, controlling cell growth, apoptosis, and development.
We show that Axin interacts with homeodomain‐interacting protein kinase‐2 (HIPK2), which …
We show that Axin interacts with homeodomain‐interacting protein kinase‐2 (HIPK2), which …
The genetics of cognitive epigenetics
Cognitive disorders (CDs) are a heterogeneous group of disorders for which the genetic
foundations are rapidly being uncovered. The large number of CD-associated gene …
foundations are rapidly being uncovered. The large number of CD-associated gene …
VHL suppresses autophagy and tumor growth through PHD1-dependent Beclin1 hydroxylation
Z Wang, M Yan, L Ye, Q Zhou, Y Duan, H Jiang… - The EMBO …, 2024 - embopress.org
Abstract The Von Hippel–Lindau (VHL) protein, which is frequently mutated in clear-cell
renal cell carcinoma (ccRCC), is a master regulator of hypoxia-inducible factor (HIF) that is …
renal cell carcinoma (ccRCC), is a master regulator of hypoxia-inducible factor (HIF) that is …
Similarities and differences between nigral and enteric dopaminergic neurons unravel distinctive involvement in Parkinson's disease
In addition to the well-known degeneration of midbrain dopaminergic neurons, enteric
neurons can also be affected in neurodegenerative disorders such as Parkinson's disease …
neurons can also be affected in neurodegenerative disorders such as Parkinson's disease …