A Vaccine Against Group B Streptococcus: Recent Advances

C Carreras-Abad, L Ramkhelawon… - Infection and drug …, 2020 - Taylor & Francis
Group B streptococcus (GBS) causes a high burden of neonatal and infant disease globally.
Implementing a vaccine for pregnant women is a promising strategy to prevent neonatal and …

Global perspectives on immunization during pregnancy and priorities for future research and development: an international consensus statement

B Abu-Raya, K Maertens, KM Edwards… - Frontiers in …, 2020 - frontiersin.org
Immunization during pregnancy has been recommended in an increasing number of
countries. The aim of this strategy is to protect pregnant women and infants from severe …

Proof of concept for a single-dose Group B Streptococcus vaccine based on capsular polysaccharide conjugated to Qβ virus-like particles

F Carboni, R Cozzi, G Romagnoli, G Tuscano… - npj Vaccines, 2023 - nature.com
A maternal vaccine to protect neonates against Group B Streptococcus invasive infection is
an unmet medical need. Such a vaccine should ideally be offered during the third trimester …

[HTML][HTML] The immunogenicity and safety of Group B Streptococcal maternal vaccines: a systematic review

AU Bjerkhaug, S Ramalingham, R Mboizi, K Le Doare… - Vaccine, 2024 - Elsevier
Purpose To systematically review immunogenicity and safety data of maternal group B
streptococcal (GBS) vaccines in published clinical trials until July 2023. Methods EMBASE …

Transmission of Group B Streptococcus in late-onset neonatal disease: A narrative review of current evidence

F Miselli, I Frabboni, M Di Martino… - Therapeutic …, 2022 - journals.sagepub.com
Group B streptococcus (GBS) late-onset disease (LOD, occurring from 7 through 89 days of
life) is an important cause of sepsis and meningitis in infants. The pathogenesis and modes …

[HTML][HTML] Safety and immunogenicity of a prototype recombinant alpha-like protein subunit vaccine (GBS-NN) against Group B Streptococcus in a randomised placebo …

P Fischer, A Pawlowski, D Cao, D Bell, G Kitson… - Vaccine, 2021 - Elsevier
Abstract Background Group B Streptococcus (GBS) is the leading cause of life-threatening
infections in new-borns and may cause invasive disease, stillbirth and preterm delivery …

[HTML][HTML] The role of immune correlates of protection on the pathway to licensure, policy decision and use of group B Streptococcus vaccines for maternal immunization …

J Vekemans, J Crofts, CJ Baker, D Goldblatt, PT Heath… - Vaccine, 2019 - Elsevier
The development of a group B Streptococcus (GBS) vaccine for maternal immunization
constitutes a global public health priority, to prevent GBS-associated early life invasive …

Strategies to Prevent Early and Late-Onset Group B Streptococcal Infection via Interventions in Pregnancy

M Delara, NK Vadlamudi, M Sadarangani - Pathogens, 2023 - mdpi.com
Group B Streptococcus is a Gram-positive bacterium that typically colonizes 10–30% of
pregnant women, causing chorioamnionitis, preterm birth, and stillbirth, as well as neonatal …

A Recombinant Alpha-Like Protein Subunit Vaccine (GBS-NN) Provides Protection in Murine Models of Group B Streptococcus Infection

A Brokaw, S Nguyen, P Quach, A Orvis… - The Journal of …, 2022 - academic.oup.com
Abstract Background Group B Streptococcus (GBS) transmission during pregnancy causes
preterm labor, stillbirths, fetal injury, or neonatal infections. Rates of adult infections are also …

Immune responses against group B Streptococcus monovalent and pentavalent capsular polysaccharide tetanus toxoid conjugate vaccines in Balb/c mice

N Dhar, E Mohamed, F Kirstein, M Williams… - Iscience, 2023 - cell.com
Immunization of pregnant women with Group B Streptococcus (GBS) capsular
polysaccharide (CPS) conjugate vaccine (CV) could protect young infants against invasive …