The ability of cells to respond to changes in nutrient availability is essential for the
maintenance of metabolic homeostasis and viability. One of the key cellular responses to …

Living cells are adaptive self-sustaining systems. They strictly depend on the sufficient
supply of oxygen, energy, and nutrients from the outside in order to sustain their internal …

Clinical trials of novel therapeutics for Alzheimer's Disease (AD) have consumed a large
amount of time and resources with largely negative results. Repurposing drugs already …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Macroautophagy is mediated by a unique organelle, the autophagosome, which encloses a
portion of cytoplasm for delivery to the lysosome. Autophagosome formation is dynamically …

Autophagy is a highly conserved process and is essential for the maintenance of cellular
homeostasis. Autophagy occurs at a basal level in all cells, but it can be up-regulated during …

Endosomal protein sorting controls the localization of many physiologically important
proteins and is linked to several neurodegenerative diseases. VPS35 is a component of the …

The Atg1/ULK1 complex plays a central role in starvation-induced autophagy, integrating
signals from upstream sensors such as MTOR and AMPK and transducing them to the …

The mammalian target of rapamycin (mTOR) is a central controller of cell growth and
proliferation. mTOR forms two distinct complexes, mTOR complex 1 (mTORC1) and mTOR …

Macroautophagy is an intracellular catabolic process involved in the formation of multiple
membrane structures ranging from phagophores to autophagosomes and autolysosomes …