Objectives/Hypothesis To perform a systematic review of GJB2‐associated hearing loss to
describe genotype distributions and auditory phenotype. Data Sources 230 primary studies …

Purpose We performed a systematic review of the ethical, social, and cultural issues
associated with delivery of genetic services in low-and middle-income countries (LMICs) …

Concurrent hearing and genetic screening of newborns is expected to play important roles
not only in early detection and diagnosis of congenital deafness, which triggers intervention …

Objectives: Genetic screening can benefit early detection and intervention for hearing loss.
The frequency of common deafness-associated variants in general populations is highly …

Background Genetic variations, including mitochondrial mutations, are important
contributors to hearing loss, especially in children, and newborn genetic screens for hearing …

Introduction Mitochondria generate cellular energy in the form of ATP through the process of
oxidative phosphorylation. The generation of ATP by mitochondria is critical for survival, and …

Objective: Universal newborn hearing screening (UNHS) uses otoacoustic emissions testing
(OAE) and auditory brainstem response testing (ABR) to screen all newborn infants for …

Mitochondria both produce the energy of the cell as ATP via respiration and regulate cellular
metabolism. Accordingly, any deletion or mutation in the mitochondrial DNA (mtDNA) may …

Latin America comprises all countries from South and Central America, in addition to
Mexico. It is characterized by a complex mosaic of regions with heterogeneous genetic …

Mitochondrial nonsyndromic hearing loss and deafness is characterized by sensorineural
hearing loss (SNHL) of variable onset and severity. Pathogenic variants in MT-RNR1 can be …