Invasion of macrophages and replication within an acidic and degradative phagolysosome-
like vacuole are essential for disease pathogenesis by Coxiella burnetii, the bacterial agent …

Highlights•Type IV secretion systems (T4SSs) have unique molecular architectures.•T4ASS
structures provide clues for understanding T4BSS architecture.•T4BSSs have a chimeric …

The bacterial type IV secretion systems (T4SSs) are a highly functionally and structurally
diverse superfamily of secretion systems found in many species of Gram-negative and …

Interactions between eukaryotic hosts and their bacterial symbionts drive key ecological and
evolutionary processes, from regulating ecosystems to the evolution of complex molecular …

Legionella pneumophila was first recognized as a cause of severe and potentially fatal
pneumonia during a large-scale outbreak of Legionnaires' disease (LD) at a Pennsylvania …

Abstract The Dot/Icm type IVB secretion system of Legionella pneumophila is essential for its
pathogenesis by delivering> 300 effector proteins into the host cell. However, their precise …

Plasmid conjugative transfer systems comprise type IV secretion systems (T4SS) coupled to
DNA processing and replication. The T4SSs are divided into two phylogenetic subfamilies …

Legionella pneumophila uses over 300 translocated effector proteins to rewire host cells
during infection and create a replicative niche for intracellular growth. To date, several …

L egionella pneumophila uses a single homodimeric disulfide bond (DSB) oxidoreductase
DsbA 2 to catalyze extracytoplasmic protein folding and to correct DSB errors through …

Legionella pneumophila survives and replicates inside host cells by secreting~ 300 effectors
through the Dot/Icm type IVB secretion system (T4BSS). Understanding this machine's …