The chemistry of abiotic nucleotide synthesis of RNA and DNA in the context of their
prebiotic origins on early earth is a continuing challenge. How did (or how can) the …

Water is essential for life as we know it, but it has paradoxically been considered inimical to
the emergence of life. Proteins and nucleic acids have sustained evolution and life for …

Understanding how life began is one of the most fascinating problems to solve. By
approaching this enigma from a chemistry perspective, the goal is to define what series of …

The structure of life's first genetic polymer is a question of intense ongoing debate. The “RNA
world theory” suggests RNA was life's first nucleic acid. However, ribonucleotides are …

Potentially prebiotic chemical reactions leading to RNA nucleotides involve periods of UV
irradiation, which are necessary to promote selectivity and destroy biologially irrelevant side …

The photochemistry of nucleic acids has been a topic of extensive research for more than
half a century [15.163] due to the relationship between ultraviolet light and human disease …

Understanding how life on Earth might have started is the major goal of prebiotic chemistry.
The universal nature of extant life, with integrated informational, catalytic and compartment …

Without transition metals (TM) Life would not exist, at least not in the form we know. In fact,
first row TM share an important ubiquitous presence in all Phyla where 30% of all proteins …

Nucleic acids are at the heart of extant biology and the structure of life's original genetic
polymer is still a question of debate. The RNA world theory proposes that RNA was the first …

Nucleic acids underpin Darwinian evolution in biology. But where do nucleic acids come
from? RNA is the leading candidate for biology's first replicating molecule, and accordingly …