Microglia in the neuroinflammatory pathogenesis of Alzheimer's disease and related therapeutic targets
Y Cai, J Liu, B Wang, M Sun, H Yang - Frontiers in immunology, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease worldwide,
characterized by progressive neuron degeneration or loss due to excessive accumulation of …
characterized by progressive neuron degeneration or loss due to excessive accumulation of …
The dialogue between neuroinflammation and adult neurogenesis: mechanisms involved and alterations in neurological diseases
Adult neurogenesis occurs mainly in the subgranular zone of the hippocampal dentate gyrus
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
and the subventricular zone of the lateral ventricles. Evidence supports the critical role of …
Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues
Spatial transcriptomics (ST) technologies generate multiple data types from biological
samples, namely gene expression, physical distance between data points, and/or tissue …
samples, namely gene expression, physical distance between data points, and/or tissue …
Traumatic brain injury causes chronic cortical inflammation and neuronal dysfunction mediated by microglia
KG Witcher, CE Bray, T Chunchai, F Zhao… - Journal of …, 2021 - Soc Neuroscience
Traumatic brain injury (TBI) can lead to significant neuropsychiatric problems and
neurodegenerative pathologies, which develop and persist years after injury …
neurodegenerative pathologies, which develop and persist years after injury …
Carrier-free nanodrug based on Co-assembly of methylprednisolone dimer and rutin for combined treatment of spinal cord injury
H Wang, F Lin, Y Wu, W Guo, X Chen, C Xiao… - ACS nano, 2023 - ACS Publications
Spinal cord injury (SCI), which is characterized by excessive inflammatory cell infiltration
and accumulation of oxidative substance, would severely impede neurological functional …
and accumulation of oxidative substance, would severely impede neurological functional …
Temporal and spatial cellular and molecular pathological alterations with single-cell resolution in the adult spinal cord after injury
C Li, Z Wu, L Zhou, J Shao, X Hu, W Xu… - Signal transduction and …, 2022 - nature.com
Spinal cord injury (SCI) involves diverse injury responses in different cell types in a
temporally and spatially specific manner. Here, using single-cell transcriptomic analyses …
temporally and spatially specific manner. Here, using single-cell transcriptomic analyses …
To kill a microglia: a case for CSF1R inhibitors
Microglia, the brain's immune sentinels, have garnered much attention in recent years.
Researchers have begun to identify the manifold roles that these cells play in the central …
Researchers have begun to identify the manifold roles that these cells play in the central …
stLearn: integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues
Spatial Transcriptomics is an emerging technology that adds spatial dimensionality and
tissue morphology to the genome-wide transcriptional profile of cells in an undissociated …
tissue morphology to the genome-wide transcriptional profile of cells in an undissociated …
[HTML][HTML] Selenium mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging
Although the neurogenesis-enhancing effects of exercise have been extensively studied, the
molecular mechanisms underlying this response remain unclear. Here, we propose that this …
molecular mechanisms underlying this response remain unclear. Here, we propose that this …
Activated microglia mitigate Aβ-associated tau seeding and spreading
In Alzheimer's disease (AD) models, AD risk variants in the microglial-expressed TREM2
gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well …
gene decrease Aβ plaque–associated microgliosis and increase neuritic dystrophy as well …