How cells become specialized, or" mature," is important for cell and developmental biology.
While maturity is usually deemed a terminal fate, it may be more helpful to consider …

Melanosomes are specialized intracellular organelles that produce and store melanin
pigments in melanocytes, which are present in several mammalian tissues and organs …

Retinal drug delivery is a challenging, but important task, because most retinal diseases are
still without any proper therapy. Drug delivery to the retina is hampered by the anatomical …

Diabetic retinopathy (DR) is a devastating disease leading to blindness among majority of
working adults around the globe. Nonetheless, an effective treatment or cure for the disease …

Highlights•Most retinal diseases underly multifactorial pathomechanisms.•The retinal
pigment epithelium (RPE) plays a key part in these pathomechanisms.•Targeted RPE …

The retinal pigmented epithelium (RPE) is a monolayer of multifunctional cells located at the
back of the eye. High membrane turnover and polarization, including formation of actin …

Simple Summary The ocular fundus contains molecules that emit fluorescence when excited
with light of an appropriate wavelength. Fundus autofluorescence imaging is based on the in …

During the progression of proliferative vitreoretinopathy (PVR) following ocular trauma,
previously quiescent retinal pigment epithelial (RPE) cells transition into a state of rapid …

RNA editing holds great promise for the therapeutic correction of pathogenic, single
nucleotide variants (SNV) in the human transcriptome since it does not risk creating …

Despite several promising candidates, there is a paucity of drug treatments available for
patients suffering from retinal diseases. An important reason for this is the lack of suitable …