Background: Sickle cell disease causes significant morbidity and mortality and affects the
economic and healthcare status of many countries. Yet historically, the disease has not had …

Lipids have many important yet distinct functions in cellular homeostasis such as forming an
impermeable barrier separating intracellular and extracellular compartments, providing a …

The primary β-globin gene mutation that causes sickle cell disease (SCD) has significant
pathophysiological consequences that result in hemolytic events and the induction of the …

ContextSickle cell disease is characterized by a state of nitric oxide resistance and limited
bioavailability of L-arginine, the substrate for nitric oxide synthesis. We hypothesized that …

In hematologic diseases, such as sickle cell disease (SCD) and hemolytic uremic syndrome
(HUS), pathological biophysical interactions among blood cells, endothelial cells, and …

In 1949 Pauling and his associates showed that sickle cell hemoglobin (HbS) belonged to
an abnormal molecular species. In 1958 Ingram, who used a two-dimensional system of …

In the 1980s, a research team led by Parisian scientists identified several unique DNA
sequences, or haplotypes, linked to sickle cell anemia in African populations. After casual …

Wound healing is a highly coordinated and complex process involving various cell types,
chemical mediators and the surrounding extracellular matrix, resulting in a tightly …

Sickle cell anaemia (SCD) is a life-threatening haematological disorder which is
predominant in sub-Saharan Africa and is triggered by a genetic mutation of the β-chain …

Sickle cell disease (SCD) leads to many complications including osteoporosis and
osteopenia. We studied the prevalence and predisposing factors of low bone mass density …