Identification and manipulation of tumor associated macrophages in human cancers

M Heusinkveld, SH van Der Burg - Journal of translational medicine, 2011 - Springer
Evading immune destruction and tumor promoting inflammation are important hallmarks in
the development of cancer. Macrophages are present in most human tumors and are often …

Tumour‐infiltrating T‐cell subsets, molecular changes in colorectal cancer, and prognosis: cohort study and literature review

K Nosho, Y Baba, N Tanaka, K Shima… - The Journal of …, 2010 - Wiley Online Library
The abundance of tumour‐infiltrating T‐cells has been associated with microsatellite
instability (MSI) and a favourable prognosis in colorectal cancer. However, numerous …

Mechanisms driving macrophage diversity and specialization in distinct tumor microenvironments and parallelisms with other tissues

E Van Overmeire, D Laoui, J Keirsse… - Frontiers in …, 2014 - frontiersin.org
Macrophages are extremely versatile cells that adopt a distinct phenotype in response to a
changing microenvironment. Consequently, macrophages are involved in diverse functions …

Leukocytes in mammary development and cancer

LM Coussens, JW Pollard - Cold Spring Harbor …, 2011 - cshperspectives.cshlp.org
Leukocytes, of both the innate and adaptive lineages, are normal cellular components of all
tissues. These important cells not only are critical for regulating normal tissue homeostasis …

[HTML][HTML] Functional characterization of osteosarcoma cell lines provides representative models to study the human disease

AB Mohseny, I Machado, Y Cai, KL Schaefer… - Laboratory …, 2011 - Elsevier
Cancer cell lines represent in vitro models for studying malignancies, general cell biology,
drug discovery and more. Whether they can be considered as exact representative models …

Detection of long non-coding RNA in archival tissue: correlation with polycomb protein expression in primary and metastatic breast carcinoma

KM Chisholm, Y Wan, R Li, KD Montgomery… - PloS one, 2012 - journals.plos.org
A major function of long non-coding RNAs (lncRNAs) is regulating gene expression through
changes in chromatin state. Experimental evidence suggests that in cancer, they can …

Listeria-based hepatocellular carcinoma vaccine facilitates anti-PD-1 therapy by regulating macrophage polarization

G Xu, D Feng, Y Yao, P Li, H Sun, H Yang, C Li… - Oncogene, 2020 - nature.com
Recently, patients with advanced cancers have been benefited greatly from immune
checkpoint blockade immunotherapy. However, immune checkpoint blockade is still …

Spatial transcriptomics reveals heterogeneity of macrophages in the tumor microenvironment of granulomatous slack skin

Y Feng, S Wang, J Xie, B Ding, M Wang… - The Journal of …, 2023 - Wiley Online Library
Granulomatous slack skin (GSS) is an extremely rare subtype of cutaneous T‐cell lymphoma
accompanied by an abundant number of macrophages and is clinically characterized by the …

Mononuclear phagocyte heterogeneity in cancer: different subsets and activation states reaching out at the tumor site

D Laoui, E Van Overmeire, K Movahedi… - Immunobiology, 2011 - Elsevier
Mononuclear phagocytes are amongst the most versatile cells of the body, contributing to
tissue genesis and homeostasis and safeguarding the balance between pro-and anti …

Concise review: mesenchymal tumors: when stem cells go mad

AB Mohseny, PCW Hogendoorn - Stem cells, 2011 - academic.oup.com
Sarcomas are nonepithelial, nonhematopoietic malignant tumors that arise from the
embryonic mesoderm. Despite their rarity, less than 10% of all cancers, sarcomas are …