[HTML][HTML] The fight against cancer by microgravity: the multicellular spheroid as a metastasis model

D Grimm, H Schulz, M Krüger… - International Journal of …, 2022 - mdpi.com
Cancer is a disease exhibiting uncontrollable cell growth and spreading to other parts of the
organism. It is a heavy, worldwide burden for mankind with high morbidity and mortality …

[HTML][HTML] Current knowledge about the impact of microgravity on gene regulation

TJ Corydon, H Schulz, P Richter, SM Strauch… - Cells, 2023 - mdpi.com
Microgravity (µ g) has a massive impact on the health of space explorers. Microgravity
changes the proliferation, differentiation, and growth of cells. As crewed spaceflights into …

[HTML][HTML] Real microgravity influences the cytoskeleton and focal adhesions in human breast cancer cells

MZ Nassef, S Kopp, M Wehland, D Melnik… - International journal of …, 2019 - mdpi.com
With the increasing number of spaceflights, it is crucial to understand the changes occurring
in human cells exposed to real microgravity (r-µ g) conditions. We tested the effect of r-µ g on …

[HTML][HTML] Morphological and molecular changes in juvenile normal human fibroblasts exposed to simulated microgravity

C Buken, J Sahana, TJ Corydon, D Melnik, J Bauer… - Scientific Reports, 2019 - nature.com
The literature suggests morphological alterations and molecular biological changes within
the cellular milieu of human cells, exposed to microgravity (µ g), as many cell types …

[HTML][HTML] The impact of spaceflight and simulated microgravity on cell adhesion

X Lin, K Zhang, D Wei, Y Tian, Y Gao, Z Chen… - International Journal of …, 2020 - mdpi.com
Microgravity induces a number of significant physiological changes in the cardiovascular,
nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell …

[HTML][HTML] Simulated microgravity influences VEGF, MAPK, and PAM signaling in prostate cancer cells

TE Hybel, D Dietrichs, J Sahana, TJ Corydon… - International Journal of …, 2020 - mdpi.com
Prostate cancer is one of the leading causes of cancer mortality in men worldwide. An
unusual but unique environment for studying tumor cell processes is provided by …

[HTML][HTML] Fighting thyroid cancer with microgravity research

M Krüger, D Melnik, S Kopp, C Buken… - International Journal of …, 2019 - mdpi.com
Microgravity in space or simulated by special ground-based devices provides an unusual
but unique environment to study and influence tumour cell processes. By investigating …

[HTML][HTML] Cancer studies under space conditions: Finding answers abroad

JL Cortés-Sánchez, J Callant, M Krüger, J Sahana… - Biomedicines, 2021 - mdpi.com
In this review article, we discuss the current state of knowledge in cancer research under
real and simulated microgravity conditions and point out further research directions in this …

[HTML][HTML] Exploration of space to achieve scientific breakthroughs

B Prasad, P Richter, N Vadakedath, R Mancinelli… - Biotechnology …, 2020 - Elsevier
Living organisms adapt to changing environments using their amazing flexibility to remodel
themselves by a process called evolution. Environmental stress causes selective pressure …

Effect of weightlessness on the 3D structure formation and physiologic function of human cancer cells

ZY Chen, S Guo, BB Li, N Jiang, A Li… - BioMed research …, 2019 - Wiley Online Library
With the rapid development of modern medical technology and the deterioration of living
environments, cancer, the most important disease that threatens human health, has attracted …