The immune system comprises diverse specialized cell types that cooperate to defend the
host against a wide range of pathogenic threats. Recent advancements in single-cell and …

The proper functioning of diverse biological systems depends on the spatial organization of
their cells, a critical factor for biological processes like shaping intricate tissue functions and …

Vedolizumab (VDZ) is a first-line treatment in ulcerative colitis (UC) that targets the α4β7-
mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) axis. To determine the …

Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is
difficult to diagnose. Inflammatory bowel disease (IBD) is a common chronic digestive …

B lymphocytes are essential mediators of humoral immunity and play multiple roles in
human cancer. To decode the functions of tumor-infiltrating B cells, we generated a B cell …

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal
tract, defined by a clinical relapse-remitting course. Affecting people worldwide, the origin of …

For decades, the therapeutic goal of conventional treatment among inflammatory bowel
disease (IBD) patients is alleviating exacerbations in acute phase, maintaining remission …

The mechanisms of how host-microbe mutualistic relationships are established at weaning
contingently upon B-cell surveillance remain inadequately elucidated. We found that …

Fibroblasts are essential components of the stroma, sustaining a variety of tissues and being
key to the process of tissue repair after injury. Their role in tissue repair has been attributed …

Tissues are dynamic and complex biological systems composed of specialized cell types
that interact with each other for proper biological function. To comprehensively characterize …