Natural killer cells in cancer biology and therapy

SY Wu, T Fu, YZ Jiang, ZM Shao - Molecular cancer, 2020 - Springer
The tumor microenvironment is highly complex, and immune escape is currently considered
an important hallmark of cancer, largely contributing to tumor progression and metastasis …

Harnessing natural killer cells for cancer immunotherapy: dispatching the first responders

NA Maskalenko, D Zhigarev… - Nature reviews Drug …, 2022 - nature.com
Natural killer (NK) cells have crucial roles in the innate immunosurveillance of cancer and
viral infections. They are 'first responders' that can spontaneously recognize abnormal cells …

Development of NK cell-based cancer immunotherapies through receptor engineering

A Page, N Chuvin, J Valladeau-Guilemond… - Cellular & Molecular …, 2024 - nature.com
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …

Overcoming tumor resistance mechanisms in CAR-NK cell therapy

A Valeri, A García-Ortiz, E Castellano… - Frontiers in …, 2022 - frontiersin.org
Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …

Engineered nanomaterials to potentiate CRISPR/Cas9 gene editing for cancer therapy

K Yi, H Kong, YH Lao, D Li, RL Mintz, T Fang… - Advanced …, 2024 - Wiley Online Library
Clustered regularly interspaced short palindromic repeats/associated protein 9
(CRISPR/Cas9) gene‐editing technology shows promise for manipulating single or multiple …

CD38 knockout natural killer cells expressing an affinity optimized CD38 chimeric antigen receptor successfully target acute myeloid leukemia with reduced effector …

M Gurney, A Stikvoort, E Nolan… - …, 2020 - pmc.ncbi.nlm.nih.gov
There is a strong biological rationale for the augmentation of allogeneic natural killer (NK)
cell therapies with a chimeric antigen receptor (CAR) to enhance acute myeloid leukemia …

[HTML][HTML] Emerging NK cell therapies for cancer and the promise of next generation engineering of iPSC-derived NK cells

S Maddineni, JL Silberstein… - … for Immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Adoptive cell therapy is a rapidly advancing approach to cancer immunotherapy that seeks
to facilitate antitumor responses by introducing potent effector cells into the tumor …

Understanding NK cell biology for harnessing NK cell therapies: targeting cancer and beyond

E Shin, SH Bak, T Park, JW Kim, SR Yoon… - Frontiers in …, 2023 - frontiersin.org
Gene-engineered immune cell therapies have partially transformed cancer treatment, as
exemplified by the use of chimeric antigen receptor (CAR)-T cells in certain hematologic …

Natural killer cell therapy for hematologic malignancies: successes, challenges, and the future

MG Lamb, HG Rangarajan, BP Tullius… - Stem Cell Research & …, 2021 - Springer
The adoptive transfer of natural killer (NK) cells is an emerging therapy in the field of
immuno-oncology. In the last 3 decades, NK cells have been utilized to harness the anti …

[HTML][HTML] iPSC-derived natural killer cells for cancer immunotherapy

P Karagiannis, SI Kim - Molecules and cells, 2021 - Elsevier
The discovery of human pluripotent stem cells (PSCs) at the turn of the century opened the
door to a new generation of regenerative medicine research. Among PSCs, the donors …