Platelets are essential for physiological hemostasis and are central in pathological
thrombosis. These are their traditional and best known activities in health and disease. In …

There is increasing research on and clinical interest in the physiological role played by
platelet microparticles (PMPs). PMPs are 0.1–1-μm fragments shed from plasma …

Alterations in the mechanical properties of erythrocytes occurring in inflammatory and
haematological disorders such as sickle-cell disease (SCD) and malaria often lead to …

Platelets are understood to assist host innate immune responses against infection, although
direct evidence of this function in any human disease, including malaria, is unknown. Here …

Recruitment and activation of monocytes and macrophages are essential for clearance of
malaria infection, but these have also been associated with adverse clinical outcomes. In …

Cerebral malaria is the most severe pathology caused by the malaria parasite, Plasmodium
falciparum. The pathogenic mechanisms leading to cerebral malaria are still poorly defined …

Background Severe malaria is a leading cause of childhood mortality in Africa. However, at
presentation, it is difficult to predict which children with severe malaria are at greatest risk of …

Plasmodium falciparum malaria is responsible for nearly one million annual deaths
worldwide. Because of the difficulty in monitoring the pathogenesis of cerebral malaria in …

Although the role of platelets as central mediators of hemostasis and thrombosis has been
the primary focus of research into platelet biology for more than a century, over the last …

Malaria-associated acute respiratory distress syndrome (MA-ARDS) is an increasingly
reported, often lethal, and incompletely understood complication of malaria. We discuss and …