The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

Zebrafish have been widely used as a model system for studying developmental processes,
but in the last decade, they have also emerged as a valuable system for modeling human …

Large-scale transcriptome sequencing efforts have vastly expanded the catalog of long non-
coding RNAs (lncRNAs) with varying evolutionary conservation, lineage expression, and …

Eosinophils are a group of granulocytes well known for their capacity to protect the host from
parasites and regulate immune function. Diverse biological roles for eosinophils have been …

The inhibitory extracellular matrix in a spinal lesion site is a major impediment to axonal
regeneration in mammals. In contrast, the extracellular matrix in zebrafish allows substantial …

Technological innovation has helped the zebrafish embryo gain ground as a disease model
and an assay system for drug screening. Here, we review the use of zebrafish embryos and …

Cilia are microtubule-based organelles that project into the extracellular space, function in
the perception and integration of environmental cues, and regulate Hedgehog signal …

Primary ciliary dyskinesia (PCD) is caused when defects of motile cilia lead to chronic
airway infections, male infertility, and situs abnormalities. Multiple causative PCD mutations …

Haematopoietic stem and progenitor cells (HSPCs) give rise to all blood lineages that
support the entire lifespan of vertebrates. After HSPCs emerge from endothelial cells within …

The zebrafish holds much promise as a high-throughput drug screening model for immune-
related diseases, including inflammatory and infectious diseases and cancer. This is due to …