Chemoprevention of colorectal cancer

BW Katona, JM Weiss - Gastroenterology, 2020 - Elsevier
Although colorectal cancer (CRC) screening has reduced the incidence of and mortality from
CRC, chemoprevention strategies have the potential to further reduce CRC incidence and …

Genetic predisposition to colorectal cancer: syndromes, genes, classification of genetic variants and implications for precision medicine

L Valle, E Vilar, SV Tavtigian… - The Journal of …, 2019 - Wiley Online Library
This article reviews genes and syndromes associated with predisposition to colorectal
cancer (CRC), with an overview of gene variant classification. We include updates on the …

[HTML][HTML] Management of familial adenomatous polyposis and MUTYH-associated polyposis; new insights

AS Aelvoet, F Buttitta, L Ricciardiello… - Best Practice & Research …, 2022 - Elsevier
Familial adenomatous polyposis (FAP) and MUTYH-associated polyposis (MAP) are rare
inherited polyposis syndromes with a high colorectal cancer (CRC) risk. Therefore, frequent …

Chemoprevention with low-dose aspirin, mesalazine, or both in patients with familial adenomatous polyposis without previous colectomy (J-FAPP Study IV): a …

H Ishikawa, M Mutoh, Y Sato, H Doyama… - The Lancet …, 2021 - thelancet.com
Background The only established treatment for preventing colorectal cancer in patients with
familial adenomatous polyposis (FAP) is colectomy, which greatly reduces patient quality of …

Use of family history and genetic testing to determine risk of colorectal cancer

F Kastrinos, NJ Samadder, RW Burt - Gastroenterology, 2020 - Elsevier
Approximately 35% of patients with colorectal cancer (CRC) have a family history of the
disease attributed to genetic factors, common exposures, or both. Some families with a …

[HTML][HTML] Colorectal cancer: Epidemiology, risk factors, and protective factors

FA Macrae, RM Goldberg… - Uptodate com [ažurirano …, 2016 - lifewithnogallbladder.org
Cholecystectomy—A relationship between cholecystectomy and right-sided colon cancer
has been described in some reports. As an example, in a study of 278,460 patients followed …

Phenolic phytochemicals for prevention and treatment of colorectal cancer: A critical evaluation of in vivo studies

S De, S Paul, A Manna, C Majumder, K Pal, N Casarcia… - Cancers, 2023 - mdpi.com
Simple Summary Colorectal cancer (CRC) is a significant cause of death worldwide. The
inefficacy of the current treatment regimens is reflected in the frequent recurrence and …

NSAIDs: Old acquaintance in the pipeline for cancer treatment and prevention─ Structural modulation, mechanisms of action, and bright future

S Ramos-Inza, AC Ruberte, C Sanmartin… - Journal of Medicinal …, 2021 - ACS Publications
The limitations of current chemotherapeutic drugs are still a major issue in cancer treatment.
Thus, targeted multimodal therapeutic approaches need to be strategically developed to …

Clinically relevant anti-inflammatory agents for chemoprevention of colorectal cancer: new perspectives

A Mohammed, NS Yarla, V Madka, CV Rao - International journal of …, 2018 - mdpi.com
Substantial efforts are underway for prevention of early stages or recurrence of colorectal
cancers (CRC) or new polyp formation by chemoprevention strategies. Several …

Updated perspectives on the diagnosis and management of familial adenomatous polyposis

F Kyriakidis, D Kogias, TM Venou… - The Application of …, 2023 - Taylor & Francis
Familial adenomatous polyposis (FAP) is an autosomal dominant cancer predisposition
syndrome marked by extensive colorectal polyposis and a high risk of colorectal cancer …