Emerging trends in the field of inflammation and proteinopathy in ALS/FTD spectrum disorder

F De Marchi, T Franjkic, P Schito, T Russo, J Nimac… - Biomedicines, 2023 - mdpi.com
Proteinopathy and neuroinflammation are two main hallmarks of neurodegenerative
diseases. They also represent rare common events in an exceptionally broad landscape of …

Neuroimmune characterization of optineurin insufficiency mouse model during ageing

N Mohovic, J Peradinovic, A Markovinovic, R Cimbro… - Scientific reports, 2023 - nature.com
Optineurin is a multifunctional polyubiquitin-binding protein implicated in inflammatory
signalling. Optineurin mutations are associated with amyotrophic lateral sclerosis (ALS) and …

Analysis of potential neuroinflammatory pathology in the spinal cords of mice with optineurin insufficiency

M Kolarić - 2023 - repository.biotech.uniri.hr
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease characterised
by motor neuron loss in the brain, brainstem, and spinal cord. ALS is caused by mutations in …