Optineurin is a multifunctional polyubiquitin-binding protein implicated in inflammatory signalling. Optineurin mutations are associated with amyotrophic lateral sclerosis (ALS) and …
Amyotrophic lateral sclerosis (ALS) is a complex neurodegenerative disease characterised by motor neuron loss in the brain, brainstem, and spinal cord. ALS is caused by mutations in …