Electrical activity of the heart is dependent on the fluxes of various ions across the cell
membrane (Fig. 1). Phase 0 of the action potential is due to a rapid influx of sodium which …

Purpose To evaluate in vitro and computationally model the effects of selected antipsychotic
drugs on several ionic currents that contribute to changes in the action potential in cardiac …

Mesoridazine, a phenothiazine antipsychotic agent, prolongs the QT interval of the cardiac
electrocardiogram and is associated with Torsade de pointes-type arrhythmias. In this study …

With an editorial team of leading experts from the American College of Emergency
Physicians and the American Heart Association, this book is the first complete, clinically …

We compared the effects of single doses of thioridazine and mesoridazine on the heart rate‐
corrected QT (QTc) interval in healthy adult volunteers. QTc intervals and plasma …

The influence of the central nervous system in the production of phenothiazine‐induced
arrhythmia and death was examined in this study, In a series of cats, spinal cords were …

Antipsychotics include the 'typical'agents (phenothiazines, thioxanthines and
butyrophenones) as well as the more recently introduced agents referred to as 'atypical' …

We present a case of malignant arrhythmias associated with hypocalcemia and subsequent
cardiac arrest in a 20-year-old woman due to ingestion of 3.1 g mesoridazine in a suicide …

This project was undertaken to determine if the phenothiazine, chlorpromazine, produces
cardiac arrhythmia via the autonomic nervous system. In the following studies, arterial blood …

The effectiveness of fluvoxamine maleate in long-term use (ie, for more than 5 to 6 weeks)
has not been systematically evaluated in controlled trials. Therefore, the physician who …